FDPS Antikörper (AA 389-419)

Produktnummer ABIN389054

Produktdetails anti-FDPS Antikörper

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Bindungsspezifität: AA 389-419

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FDPS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS.

Klon: RB04786

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-FDPS Antikörper (ABIN389054)

Sousa, Auriola, Mönkkönen, Määttä: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." in: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).

Todenhöfer, Hennenlotter, Kühs, Gerber, Gakis, Vogel, Aufderklamm, Merseburger, Knapp, Stenzl, Schwentner: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" in: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).

Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." in: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).

Räikkönen, Mönkkönen, Auriola, Mönkkönen: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." in: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).

Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).

Details zu FDPS

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Andere Bezeichnung: FDPS (FDPS Produkte)

Synonyme: CG12389 antikoerper, DmFPPS antikoerper, DmFPPSase antikoerper, DmFPS antikoerper, Dmel\\CG12389 antikoerper, FPS antikoerper, fpps antikoerper, fps antikoerper, l(2)k06103 antikoerper, v(2)k03514 antikoerper, NCU01175.1 antikoerper, 16.m00760 antikoerper, DDBDRAFT_0206220 antikoerper, DDBDRAFT_0215017 antikoerper, DDB_0206220 antikoerper, DDB_0215017 antikoerper, FPPS antikoerper, Ac2-125 antikoerper, (2E antikoerper, 6030492I17Rik antikoerper, AI256750 antikoerper, Fdpsl1 antikoerper, mKIAA1293 antikoerper, Farnesyl pyrophosphate synthase antikoerper, farnesyl diphosphate synthase antikoerper, farnesyl diphosphate synthase L homeolog antikoerper, farnesyl pyrophosphate synthase antikoerper, farnesyl pyrophosphate synthetase antikoerper, farnesyl-pyrophosphate synthetase antikoerper, FDP synthase antikoerper, Farnesyl pyrophosphate synthetase antikoerper, farnesyl diphosphate synthetase antikoerper, farnesyl pyrophosphate synthase 1 antikoerper, Fpps antikoerper, fdps antikoerper, fdps.L antikoerper, MGG_08649 antikoerper, TP03_0857 antikoerper, Tb09.160.4300 antikoerper, fpp antikoerper, BBOV_I000120 antikoerper, fps antikoerper, fpps antikoerper, FDPS antikoerper, Fdps antikoerper, fps1 antikoerper

Hintergrund: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Molekulargewicht: 48275

Gen-ID: 2224

NCBI Accession: NP_001129293, NP_001129294, NP_001229753, NP_001229754, NP_001995

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation