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FDFT1 Antikörper (AA 140-170)

FDFT1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB4781-4782 unconjugated
Produktnummer ABIN389052
  • Target Alle FDFT1 Antikörper anzeigen
    FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))
    Bindungsspezifität
    • 9
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 140-170
    Reaktivität
    • 70
    • 28
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 72
    • 5
    Kaninchen
    Klonalität
    • 71
    • 6
    Polyklonal
    Konjugat
    • 36
    • 10
    • 9
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FDFT1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 43
    • 33
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human FDFT1.
    Klon
    RB4781-4782
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product FDFT1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

    Hammer, Bien, Salazar, Steil, Scharf, Hildebrandt, Schroeder, Kroemer, Völker, Ritter: "Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches." in: Proteomics, Vol. 10, Issue 1, pp. 99-114, (2010) (PubMed).

    Størvold, Fleten, Olsen, Follestad, Krokan, Schønberg: "Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells." in: Lipids, Vol. 44, Issue 8, pp. 673-83, (2009) (PubMed).

  • Target
    FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))
    Andere Bezeichnung
    FDFT1 (FDFT1 Produkte)
    Synonyme
    FDFT1 antikoerper, DKFZp459C1712 antikoerper, SQS antikoerper, SS antikoerper, DGPT antikoerper, ERG9 antikoerper, fdft1 antikoerper, farnesyl-diphosphate farnesyltransferase 1 antikoerper, squalene synthase antikoerper, farnesyl diphosphate farnesyl transferase 1 antikoerper, FDFT1 antikoerper, fdft1 antikoerper, LOC100560926 antikoerper, Fdft1 antikoerper
    Hintergrund
    FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
    Molekulargewicht
    48115
    Gen-ID
    2222
    NCBI Accession
    NP_004453
    UniProt
    P37268
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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