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EPS15 Antikörper (C-Term)

EPS15 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB04393-04394 unconjugated
Produktnummer ABIN388933
  • Target Alle EPS15 Antikörper anzeigen
    EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
    Bindungsspezifität
    • 15
    • 11
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 840-870, C-Term
    Reaktivität
    • 51
    • 16
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 50
    • 1
    Kaninchen
    Klonalität
    • 50
    • 1
    Polyklonal
    Konjugat
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EPS15 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 19
    • 14
    • 13
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This EPS15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-870 amino acids from the C-terminal region of human EPS15.
    Klon
    RB04393-04394
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product EPS15 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
    Andere Bezeichnung
    EPS15 (EPS15 Produkte)
    Synonyme
    AF-1P antikoerper, AF1P antikoerper, MLLT5 antikoerper, CG16932 antikoerper, Dmel\\CG16932 antikoerper, EH1 antikoerper, EPS-15 antikoerper, Eps15 antikoerper, anon-WO0118547.85 antikoerper, eps-15 antikoerper, eps15 antikoerper, i31 antikoerper, 2410112D09Rik antikoerper, RGD1307641 antikoerper, epidermal growth factor receptor pathway substrate 15 antikoerper, Epidermal growth factor receptor pathway substrate clone 15 antikoerper, hypothetical protein antikoerper, EPS15 antikoerper, Eps-15 antikoerper, eps15 antikoerper, Eps15 antikoerper, PGTG_06574 antikoerper
    Hintergrund
    EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t(1,11)(p32,q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.
    Molekulargewicht
    98656
    Gen-ID
    2060
    NCBI Accession
    NP_001153441, NP_001972
    UniProt
    P42566
    Pathways
    EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation
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