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MAP1LC3A Antikörper (cleaved)

MAP1LC3A Reaktivität: Human, Maus WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal RB38908 unconjugated
Produktnummer ABIN388483
  • Target Alle MAP1LC3A Antikörper anzeigen
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Bindungsspezifität
    • 23
    • 21
    • 20
    • 15
    • 13
    • 11
    • 10
    • 10
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 89-120, cleaved
    Reaktivität
    • 212
    • 105
    • 87
    • 12
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 174
    • 44
    • 2
    Kaninchen
    Klonalität
    • 165
    • 55
    Polyklonal
    Konjugat
    • 109
    • 18
    • 15
    • 14
    • 14
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser MAP1LC3A Antikörper ist unkonjugiert
    Applikation
    • 198
    • 95
    • 74
    • 46
    • 32
    • 31
    • 29
    • 14
    • 14
    • 14
    • 11
    • 10
    • 9
    • 6
    • 5
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Homologie
    Zf, B, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Cleaved LC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-120 amino acids from human Cleaved LC3A or LC3B.
    Klon
    RB38908
    Isotyp
    IgG
  • Applikationshinweise
    IF: 1:25. IF: 1:25. WB: 1:500. WB: 1:500. WB: 1:500. WB: 1:500. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Giatromanolaki, Sivridis, Kalamida, Koukourakis: "Transcription Factor EB Expression in Early Breast Cancer Relates to Lysosomal/Autophagosomal Markers and Prognosis." in: Clinical breast cancer, Vol. 17, Issue 3, pp. e119-e125, (2018) (PubMed).

    Tavera-Mendoza, Westerling, Libby, Marusyk, Cato, Cassani, Cameron, Ficarro, Marto, Klawitter, Brown: "Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 11, pp. E2186-E2194, (2018) (PubMed).

    Bingel, Koeneke, Ridinger, Bittmann, Sill, Peterziel, Wrobel, Rettig, Milde, Fernekorn, Weise, Schober, Witt, Oehme: "Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance." in: Cell death & disease, Vol. 8, Issue 8, pp. e3013, (2018) (PubMed).

    Miyamoto, Takano, Aoyama, Soyama, Yoshikawa, Tsuda, Furuya: "Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas." in: Journal of gynecologic oncology, Vol. 28, Issue 3, pp. e33, (2017) (PubMed).

    Martinet, Roth, De Meyer: "Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue." in: Cells, Vol. 6, Issue 3, (2017) (PubMed).

    Shrestha, Assani, Rinehardt, Albastroiu, Zhang, Shell, Amer, Schlesinger, Kopp: "Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages." in: PLoS ONE, Vol. 12, Issue 10, pp. e0186169, (2017) (PubMed).

    Giatromanolaki, Kalamida, Sivridis, Karagounis, Gatter, Harris, Koukourakis: "Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer." in: Lung cancer (Amsterdam, Netherlands), Vol. 90, Issue 1, pp. 98-105, (2016) (PubMed).

    Tanaka, Whelan, Chandramouleeswaran, Kagawa, Rustgi, Noguchi, Guha, Srinivasan, Amanuma, Ohashi, Muto, Klein-Szanto, Noguchi, Avadhani, Nakagawa: "ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds." in: American journal of cancer research, Vol. 6, Issue 4, pp. 781-96, (2016) (PubMed).

    Vanoli, Necchi, Barozzi, Manca, Pecci, Solcia: "Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins." in: Histochemistry and cell biology, Vol. 144, Issue 2, pp. 179-84, (2015) (PubMed).

    Pecci, Necchi, Barozzi, Vitali, Boveri, Elena, Bernasconi, Noris, Solcia: "Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms." in: Journal of hematology & oncology, Vol. 8, pp. 71, (2015) (PubMed).

    Kong, Whelan, Laczkó, Dang, Caro Monroig, Soroush, Falcone, Amaravadi, Rustgi, Ginsberg, Falk, Nakagawa, Lynch: "Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress." in: Molecular carcinogenesis, (2015) (PubMed).

    Assani, Tazi, Amer, Kopp: "IFN-? stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages." in: PLoS ONE, Vol. 9, Issue 5, pp. e96681, (2014) (PubMed).

    Armani, Cinti, Marzolla, Morgan, Cranston, Antelmi, Carpinelli, Canese, Pagotto, Quarta, Malorni, Matarrese, Marconi, Fabbri, Rosano, Cinti, Young, Caprio: "Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3745-57, (2014) (PubMed).

    Liao, Sun, Wang, Huang, Liu, Liao, Shi: "LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer." in: Anatomical record (Hoboken, N.J. : 2007), Vol. 297, Issue 4, pp. 653-62, (2014) (PubMed).

    Sivridis, Koukourakis, Mendrinos, Touloupidis, Giatromanolaki: "Patterns of autophagy in urothelial cell carcinomas--the significance of "stone-like" structures (SLS) in transurethral resection biopsies." in: Urologic oncology, Vol. 31, Issue 7, pp. 1254-60, (2013) (PubMed).

    Koukourakis, Giatromanolaki, Zois, Sivridis: "LC3 immunostaining pitfalls." in: Histopathology, Vol. 62, Issue 6, pp. 962-3, (2013) (PubMed).

    Giatromanolaki, Koukourakis, Pouliliou, Gatter, Pezzella, Harris, Sivridis: "Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas." in: Hematology/oncology and stem cell therapy, Vol. 6, Issue 1, pp. 20-5, (2013) (PubMed).

    Radtke, English, Rondeau, Leib, Lippé, Desjardins: "Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy." in: Journal of virology, Vol. 87, Issue 7, pp. 3990-7, (2013) (PubMed).

    Abdulrahman, Khweek, Akhter, Caution, Tazi, Hassan, Zhang, Rowland, Malhotra, Aeffner, Davis, Valvano, Amer: "Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ?F508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery." in: The Journal of biological chemistry, Vol. 288, Issue 3, pp. 2049-58, (2013) (PubMed).

    Giatromanolaki, Sivridis, Mendrinos, Koutsopoulos, Koukourakis: "Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score." in: Urologic oncology, Vol. 32, Issue 1, pp. 39.e11-8, (2013) (PubMed).

  • Target
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Andere Bezeichnung
    LC3A (MAP1LC3A Produkte)
    Synonyme
    ATG8E antikoerper, LC3 antikoerper, LC3A antikoerper, MAP1ALC3 antikoerper, MAP1BLC3 antikoerper, 1010001H21Rik antikoerper, 4922501H04Rik antikoerper, LC3a antikoerper, MGC69006 antikoerper, zgc:77094 antikoerper, MGC89867 antikoerper, MAP1LC3A antikoerper, map1lc3a antikoerper, microtubule associated protein 1 light chain 3 alpha antikoerper, microtubule-associated protein 1 light chain 3 alpha antikoerper, microtubule associated protein 1 light chain 3 alpha S homeolog antikoerper, MAP1LC3A antikoerper, Map1lc3a antikoerper, map1lc3a.S antikoerper, map1lc3a antikoerper
    Hintergrund
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
    Gen-ID
    84557
    NCBI Accession
    NP_115903, NP_852610
    UniProt
    Q9H492, Q9GZQ8
    Pathways
    Autophagie
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