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HGF Antikörper (C-Term)

HGF Reaktivität: Human WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB09924 unconjugated
Produktnummer ABIN388462
  • Target Alle HGF Antikörper anzeigen
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Bindungsspezifität
    • 15
    • 15
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 521-554, C-Term
    Reaktivität
    • 81
    • 33
    • 32
    • 16
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 70
    • 22
    • 4
    • 1
    Kaninchen
    Klonalität
    • 76
    • 21
    Polyklonal
    Konjugat
    • 47
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HGF Antikörper ist unkonjugiert
    Applikation
    • 88
    • 38
    • 30
    • 14
    • 13
    • 13
    • 11
    • 11
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from the C-terminal region of human HGF.
    Klon
    RB09924
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product HGF Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Phan, Fuentes-Mattei, Wu, Velazquez-Torres, Sircar, Wood, Hai, Jimenez, Cote, Ozsari, Hofmann, Zheng, Verhaak, Pagliaro, Cortez, Lee, Yeung, Habra: "Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma." in: Cancer research, Vol. 75, Issue 19, pp. 4131-42, (2015) (PubMed).

    Vogel, Chatterjee, Metzger, Borst, Geisler, Seizer, Müller, Mack, Schumann, Bhring, Lang, Sorg, Langer, Gawaz et al.: "Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth ..." in: The Journal of biological chemistry, Vol. 289, Issue 16, pp. 11068-82, (2014) (PubMed).

  • Target
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Andere Bezeichnung
    HGF (HGF Produkte)
    Synonyme
    DFNB39 antikoerper, F-TCF antikoerper, HGFB antikoerper, HPTA antikoerper, SF antikoerper, HGF antikoerper, C230052L06Rik antikoerper, HGF/SF antikoerper, NK1 antikoerper, NK2 antikoerper, SF/HGF antikoerper, hepatocyte growth factor antikoerper, HGF antikoerper, Hgf antikoerper
    Hintergrund
    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. Transcript Variant: This variant (1) encodes the longest isoform (1). To date, experimental evidence for cleavage of the proprotein into two mature chains has been shown only for isoform 1.
    Molekulargewicht
    83134
    Gen-ID
    3082
    NCBI Accession
    NP_000592, NP_001010931, NP_001010932, NP_001010933, NP_001010934
    UniProt
    P14210
    Pathways
    RTK Signalweg, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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