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Bcl-2 Antikörper (AA 75-110)

BCL2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB04684 unconjugated
Produktnummer ABIN388095
  • Target Alle Bcl-2 (BCL2) Antikörper anzeigen
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Bindungsspezifität
    • 54
    • 37
    • 23
    • 22
    • 21
    • 18
    • 17
    • 16
    • 16
    • 16
    • 15
    • 14
    • 13
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-110
    Reaktivität
    • 453
    • 190
    • 187
    • 38
    • 34
    • 22
    • 22
    • 19
    • 17
    • 16
    • 12
    • 5
    • 5
    • 1
    • 1
    • 1
    Human
    Wirt
    • 357
    • 124
    • 6
    • 2
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 353
    • 138
    Polyklonal
    Konjugat
    • 217
    • 35
    • 34
    • 25
    • 25
    • 15
    • 14
    • 13
    • 11
    • 11
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Bcl-2 Antikörper ist unkonjugiert
    Applikation
    • 395
    • 201
    • 168
    • 123
    • 107
    • 102
    • 92
    • 75
    • 63
    • 33
    • 29
    • 25
    • 18
    • 8
    • 8
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-110 amino acids from human Bcl.
    Klon
    RB04684
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BCL2 Primärantikörper
  • Applikationshinweise
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Wang, Kong, Lin, Li, Izumiya, Ding, Zhang, Hu, Yang, Gao, Lam, Li: "A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer." in: Acta pharmacologica Sinica, Vol. 38, Issue 6, pp. 931-942, (2018) (PubMed).

    Cui, Lin, Shi, Pan: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).

    Zheng, Xu, Sun, Yin, Dong, Zeng: "Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells." in: Chemico-biological interactions, Vol. 275, pp. 74-85, (2017) (PubMed).

    Hu, Kuo, Senadi, Chang, Wang: "Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells." in: Anticancer research, Vol. 37, Issue 10, pp. 5499-5505, (2017) (PubMed).

    Kiss, Tóth, Sarang, Garabuczi, Szondy: "Retinoids induce Nur77-dependent apoptosis in mouse thymocytes." in: Biochimica et biophysica acta, Vol. 1853, Issue 3, pp. 660-70, (2015) (PubMed).

    Hu, Baldwin: "Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 6, pp. 2643-53, (2015) (PubMed).

    Cai, Xia, Yang, Liu, Shao, Liu, Yang, Xiong: "Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: involvement of the mitochondrial apoptotic pathway." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, (2015) (PubMed).

    Li, Wang, Wang, Gao, Zhang, Lu: "Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells." in: Medical oncology (Northwood, London, England), Vol. 32, Issue 1, pp. 365, (2014) (PubMed).

    Pickles, Destroismaisons, Peyrard, Cadot, Rouleau, Brown, Julien, Arbour, Vande Velde: "Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1." in: Human molecular genetics, Vol. 22, Issue 19, pp. 3947-59, (2013) (PubMed).

    Chiavarina, Whitaker-Menezes, Martinez-Outschoorn, Witkiewicz, Birbe, Howell, Pestell, Smith, Daniel, Sotgia, Lisanti: "Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth." in: Cancer biology & therapy, Vol. 12, Issue 12, pp. 1101-13, (2012) (PubMed).

    Zhao, He, Liu, Zhu, Tian, Gao, He, Yue, Lei, Ni, Wang, Jin, Hao, Lin, Chen: "Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1054-65, (2012) (PubMed).

    Guareschi, Cova, Cereda, Ceroni, Donetti, Bosco, Trotti, Pasinelli: "An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 13, pp. 5074-9, (2012) (PubMed).

    Zheng, Zhou, Ye, Li, Bai, Zhang: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells." in: World journal of surgical oncology, Vol. 8, Issue 1, pp. 31, (2010) (PubMed).

    Pedrini, Sau, Guareschi, Bogush, Brown, Naniche, Kia, Trotti, Pasinelli: "ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2." in: Human molecular genetics, Vol. 19, Issue 15, pp. 2974-86, (2010) (PubMed).

    Ferlini, Cicchillitti, Raspaglio, Bartollino, Cimitan, Bertucci, Mozzetti, Gallo, Persico, Fattorusso, Campiani, Scambia: "Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77." in: Cancer research, Vol. 69, Issue 17, pp. 6906-14, (2009) (PubMed).

    Deng, Gao, May: "Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding." in: Blood, Vol. 113, Issue 2, pp. 422-8, (2009) (PubMed).

    Kolluri, Zhu, Zhou, Lin, Chen, Sun, Tian, Town, Cao, Lin, Zhai, Kitada, Luciano, ODonnell, Cao, He, Lin, Reed, Satterthwait, Zhang: "A short Nur77-derived peptide converts Bcl-2 from a protector to a killer." in: Cancer cell, Vol. 14, Issue 4, pp. 285-98, (2008) (PubMed).

    Thompson, Winoto: "During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain." in: The Journal of experimental medicine, Vol. 205, Issue 5, pp. 1029-36, (2008) (PubMed).

    Del Gaizo Moore, Schlis, Sallan, Armstrong, Letai: "BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia." in: Blood, Vol. 111, Issue 4, pp. 2300-9, (2008) (PubMed).

    Liu, Zhou, Li, Sun, Lin, Lang, He, Cao, Yan, Wang, Lu, Han, Cao, Zhang, Zeng: "Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues." in: Cancer research, Vol. 68, Issue 21, pp. 8871-80, (2008) (PubMed).

  • Target
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Andere Bezeichnung
    Bcl-2 (BCL2 Produkte)
    Synonyme
    Bcl-2 antikoerper, PPP1R50 antikoerper, bcl-2 antikoerper, AW986256 antikoerper, C430015F12Rik antikoerper, D630044D05Rik antikoerper, D830018M01Rik antikoerper, BCL-2 antikoerper, Bcl2 antikoerper, BCL2, apoptosis regulator antikoerper, B cell leukemia/lymphoma 2 antikoerper, B-cell CLL/lymphoma 2a antikoerper, B-cell CLL/lymphoma 2 protein antikoerper, BCL2 antikoerper, Bcl2 antikoerper, bcl2a antikoerper, BCL-2 antikoerper
    Hintergrund
    BCL2 is integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.
    Molekulargewicht
    26266
    Gen-ID
    596
    NCBI Accession
    NP_000624
    UniProt
    P10415
    Pathways
    MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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