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CBLC Antikörper (C-Term)

CBLC Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB0696 unconjugated
Produktnummer ABIN388072
  • Target Alle CBLC Antikörper anzeigen
    CBLC (Cbl proto-oncogene C (CBLC))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 424-453, C-Term
    Reaktivität
    • 46
    • 2
    • 1
    Human
    Wirt
    • 41
    • 5
    Kaninchen
    Klonalität
    • 41
    • 5
    Polyklonal
    Konjugat
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    Dieser CBLC Antikörper ist unkonjugiert
    Applikation
    • 45
    • 34
    • 29
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-453 amino acids from the C-terminal region of human CBLC.
    Klon
    RB0696
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CBLC Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    CBLC (Cbl proto-oncogene C (CBLC))
    Andere Bezeichnung
    CBLC (CBLC Produkte)
    Synonyme
    CBL-3 antikoerper, CBL-SL antikoerper, RNF57 antikoerper, Cbl proto-oncogene C antikoerper, CBLC antikoerper, Cblc antikoerper
    Hintergrund
    Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
    Molekulargewicht
    52456
    Gen-ID
    23624
    NCBI Accession
    NP_001124324, NP_036248
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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