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MDM2 Antikörper (AA 141-176)
MDM2
Reaktivität: Human
WB, IF, IHC (p), FACS
Wirt: Kaninchen
Polyclonal
RB7981
unconjugated
Produktdetails anti-MDM2 Antikörper
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Target
Alle MDM2 Antikörper anzeigen
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Bindungsspezifität
Alle Epitope für MDM2 Antikörper
AA 141-176
Reaktivität
Alle Reaktivitäten für MDM2 Antikörper
Human
Wirt
Alle Wirte für MDM2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MDM2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für MDM2 Antikörper
Dieser MDM2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MDM2 Antikörper
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This MDM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2.
Klon
RB7981
Isotyp
Ig Fraction
Top Product
Discover our top product MDM2 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
IF: 1:10~50. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Referenzen für anti-MDM2 Antikörper (ABIN388067)
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Fragou, Tzimagiorgis, Karageorgopoulos, Barbetakis, Lazopoulos, Papaioannou, Haitoglou, Kouidou : "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression. " in: Molecular medicine reports , Vol. 15 , Issue 4 , pp. 1455-1460 , (2017 ) (PubMed ).
Lei, Velez, Kazlauskas : "Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. " in: Molecular and cellular biology , Vol. 31 , Issue 9 , pp. 1788-99 , (2011 ) (PubMed ).
Details zu MDM2
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Target
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Andere Bezeichnung
MDM2 (MDM2 Produkte )
Synonyme
ACTFS antikoerper, HDMX antikoerper, hdm2 antikoerper, zgc:109834 antikoerper, 1700007J15Rik antikoerper, AA415488 antikoerper, Mdm-2 antikoerper, MDM2 proto-oncogene antikoerper, MDM2 proto-oncogene S homeolog antikoerper, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antikoerper, MDM2 oncogene, E3 ubiquitin protein ligase antikoerper, transformed mouse 3T3 cell double minute 2 antikoerper, MDM2 antikoerper, mdm2.S antikoerper, Mdm2 antikoerper, mdm2 antikoerper
Hintergrund
MDM2 is a target of the transcription factor tumor protein p53. This protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Molekulargewicht
55233
Gen-ID
4193
NCBI Accession
NP_001138811 , NP_001265391 , NP_002383
UniProt
Q00987
Pathways
p53 Signalweg , PI3K-Akt Signalweg , Zellzyklus , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Autophagie , Ubiquitin Proteasome Pathway
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