Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PIAS2 Antikörper (C-Term)

PIAS2 Reaktivität: Human IHC (p) Wirt: Kaninchen Polyclonal RB0701 unconjugated
Produktnummer ABIN388059
  • Target Alle PIAS2 Antikörper anzeigen
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Bindungsspezifität
    • 15
    • 10
    • 9
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 518-547, C-Term
    Reaktivität
    • 63
    • 25
    • 21
    • 10
    • 8
    • 8
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    Human
    Wirt
    • 56
    • 6
    • 2
    • 1
    Kaninchen
    Klonalität
    • 60
    • 5
    Polyklonal
    Konjugat
    • 44
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PIAS2 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 27
    • 19
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PIAS2 (PIASx1/2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-547 amino acids from the C-terminal region of human PIAS2 (PIASx1/2).
    Klon
    RB0701
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PIAS2 Primärantikörper
  • Applikationshinweise
    IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Andere Bezeichnung
    PIAS2 (PIASx1/2) (PIAS2 Produkte)
    Synonyme
    MGC83751 antikoerper, piasx antikoerper, wu:fi05f09 antikoerper, PIAS2 antikoerper, 6330408K17Rik antikoerper, AI462206 antikoerper, ARIP3 antikoerper, AU018068 antikoerper, Dib antikoerper, Miz1 antikoerper, PIASxalpha antikoerper, PIASxb antikoerper, PIASxbeta antikoerper, SIZ2 antikoerper, DIP antikoerper, MIZ antikoerper, MIZ1 antikoerper, PIASX antikoerper, PIASX-ALPHA antikoerper, PIASX-BETA antikoerper, ZMIZ4 antikoerper, protein inhibitor of activated STAT 2 L homeolog antikoerper, protein inhibitor of activated STAT 2 antikoerper, protein inhibitor of activated STAT, 2 antikoerper, pias2.L antikoerper, PIAS2 antikoerper, pias2 antikoerper, Pias2 antikoerper
    Hintergrund
    PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
    Molekulargewicht
    68240
    Gen-ID
    9063
    NCBI Accession
    NP_004662, NP_775298
    UniProt
    O75928
    Pathways
    JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Sie sind hier:
Kundenservice