DR5 Antikörper

Antigen: DR5

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB), Durchflusszytometrie (FACS)

Produktnummer: ABIN376980

Produktbeschreibung

Immunogen: Recombinant DR5

Isotyp: IgG  (Passende Sekundärantikörper)

Spezifität: Human DR5 DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 amino acid motif known as the ‘death domain’ (DD). 1, 2, 3, 4 DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. 5, 6 DR5 has also been shown to activate NF- κB.

Anwendungen

Applikationshinweise: To insure lot-to-lot consistency, each batch of product is tested by flow cytometry and/or western blotting to conform with the characteristics of a standard reference reagent. .

Reinigung: Affinity chromatography

Buffer: The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8°C. Reagents are stable for the period shown on the label

Lagerung: Store at 2-8°C

Forschungsgebiet: Krebs, Wachstumsfaktoren, Apoptose/Nekrose, Todesrezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar