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NEDD9 Antikörper (Internal Region)

NEDD9 Reaktivität: Human, Ratte, Maus, Hund WB, EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN375218
  • Target Alle NEDD9 Antikörper anzeigen
    NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9))
    Bindungsspezifität
    • 9
    • 9
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 47
    • 12
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Hund
    Wirt
    • 39
    • 7
    • 1
    Ziege
    Klonalität
    • 41
    • 6
    Polyklonal
    Konjugat
    • 25
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser NEDD9 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 18
    • 14
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to NEDD9. This antibody is expected to recognise isoform 1 only.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Rat, Canine.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography
    Immunogen
    Peptide with sequence NKPQNKCDDLDR, from the internal region of the protein sequence
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  • Applikationshinweise
    Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9))
    Andere Bezeichnung
    NEDD9 (NEDD9 Produkte)
    Synonyme
    NEDD9 antikoerper, CAS-L antikoerper, CAS2 antikoerper, CASL antikoerper, CASS2 antikoerper, HEF1 antikoerper, Cas-L antikoerper, CasL antikoerper, E230025G09Rik antikoerper, neural precursor cell expressed, developmentally down-regulated 9 antikoerper, neural precursor cell expressed, developmentally down-regulated gene 9 antikoerper, NEDD9 antikoerper, Nedd9 antikoerper
    Hintergrund
    HEF1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases, two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.Synonyms: CASL, CASS2, Enhancer of filamentation 1, Neural precursor cell expressed developmentally down-regulated protein 9, hEF1
    Gen-ID
    4739
    NCBI Accession
    NP_001135865
    UniProt
    Q14511
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