HAP1 Antikörper (Internal Region)

Produktnummer ABIN375206

Produktdetails anti-HAP1 Antikörper

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser HAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to HAP1. This antibody is expected to recognize all reported isoforms.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-RYDFRYSEDREQ, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: ELISA: 1/32000. Western blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HAP1

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Andere Bezeichnung: HAP1 (HAP1 Produkte)

Synonyme: HAP2 antikoerper, HIP5 antikoerper, HLP antikoerper, hHLP1 antikoerper, HAP1-A antikoerper, HAP1-B antikoerper, HAP-1 antikoerper, huntingtin associated protein 1 antikoerper, huntingtin-associated protein 1 antikoerper, HAP1 antikoerper, Hap1 antikoerper

Hintergrund: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. Huntingtin-associated protein-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1

Gen-ID: 9001

NCBI Accession: NP_001073339

UniProt: P54257

Pathways: Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus