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APBA1 Antikörper (Internal Region)

APBA1 Reaktivität: Human, Maus, Ratte WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374796
  • Target Alle APBA1 Antikörper anzeigen
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    Bindungsspezifität
    • 15
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 25
    • 1
    Ziege
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser APBA1 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 13
    • 13
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    C-EASHPSQDGK RQYK
    Spezifität
    This antibody detects APBA1 / MINT1.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide from the internal region of the protein sequence according to NP_001154.2. Genename: APBA1
    Top Product
    Discover our top product APBA1 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Detection Limit: 1/16000. Western blot: 0.1-0.3 μg/mL. Approx 100 kDa band observed in Human Brain (Cerebellumand Hippocampus) lysates (calculated MW of 92.0 kDa according to NP_001154.2).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    Andere Bezeichnung
    APBA1 / MINT1 (APBA1 Produkte)
    Synonyme
    APBA1 antikoerper, 6430513E09Rik antikoerper, Lin-10 antikoerper, Mint antikoerper, Mint1 antikoerper, Urop11 antikoerper, X11 antikoerper, X11alpha antikoerper, D9S411E antikoerper, LIN10 antikoerper, MINT1 antikoerper, X11A antikoerper, X11ALPHA antikoerper, amyloid beta precursor protein binding family A member 1 antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1b antikoerper, ketopantoate reductase antikoerper, 2-dehydropantoate 2-reductase antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1 antikoerper, amyloid beta (A4) precursor protein binding, family A, member 1 antikoerper, APBA1 antikoerper, apba1b antikoerper, apbA1 antikoerper, apba1 antikoerper, Apba1 antikoerper
    Hintergrund
    APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific heterotrimeric complex with LIN-10/X11-alpha, LIN-2/CASK, and LIN7. It binds to the cytoplasmic domain of amyloid protein (APP). ABPA1 has a putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. It may modulate processing of the beta amyloid precursor protein (APP) and hence formation of beta APP. The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1
    Gen-ID
    320, 9606
    UniProt
    Q02410
    Pathways
    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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