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ERBB3 Antikörper (C-Term, Isoform 1)

ERBB3 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374599
  • Target Alle ERBB3 Antikörper anzeigen
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Bindungsspezifität
    • 29
    • 26
    • 21
    • 15
    • 15
    • 14
    • 12
    • 12
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term, Isoform 1
    Reaktivität
    • 193
    • 130
    • 113
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Rind (Kuh), Schwein
    Wirt
    • 194
    • 35
    • 1
    • 1
    Ziege
    Klonalität
    • 191
    • 40
    Polyklonal
    Konjugat
    • 118
    • 15
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    Dieser ERBB3 Antikörper ist unkonjugiert
    Applikation
    • 111
    • 72
    • 55
    • 53
    • 53
    • 32
    • 30
    • 28
    • 23
    • 17
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody is expected to recognise isoform 1 of ERBB3 only.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Rat, Canine, Porcine, Bovine.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography
    Immunogen
    Peptide with sequence C-HSRLFPKANAQRT, from the C Terminus of the protein sequence
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    Discover our top product ERBB3 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Andere Bezeichnung
    ERBB3 / HER3 (ERBB3 Produkte)
    Synonyme
    ErbB-3 antikoerper, HER3 antikoerper, LCCS2 antikoerper, MDA-BF-1 antikoerper, c-erbB-3 antikoerper, c-erbB3 antikoerper, erbB3-S antikoerper, p180-ErbB3 antikoerper, p45-sErbB3 antikoerper, p85-sErbB3 antikoerper, ERBB3 antikoerper, C76256 antikoerper, Erbb-3 antikoerper, Erbb3r antikoerper, Her3 antikoerper, nuc-ErbB3 antikoerper, erb-b2 receptor tyrosine kinase 3 antikoerper, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antikoerper, ERBB3 antikoerper, Erbb3 antikoerper
    Hintergrund
    The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3
    Gen-ID
    2065
    NCBI Accession
    NP_001005915
    UniProt
    P21860
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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