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CARD11 Antikörper (C-Term)

CARD11 Reaktivität: Human, Maus, Rind (Kuh), Hund WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374314
  • Target Alle CARD11 Antikörper anzeigen
    CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))
    Bindungsspezifität
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 34
    • 12
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Rind (Kuh), Hund
    Wirt
    • 32
    • 1
    • 1
    • 1
    Ziege
    Klonalität
    • 34
    • 1
    Polyklonal
    Konjugat
    • 28
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CARD11 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 11
    • 10
    • 9
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    C-QRKTIWVDED QL
    Spezifität
    This antibody detects CARD11 / CARMA1 at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Dog, CowSpecies reactivity (tested):Human
    Aufreinigung
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogen
    Peptide from the C Terminus of the protein sequence according to NP_115791.3 Genename: CARD11
    Top Product
    Discover our top product CARD11 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Limit dilution 1: 32000. Western Blot: 1-3 μg/mL. Approx 150+65 kDa bands observed in lysates of cell line Jurkat(calculated MW of 135 kDa according to NP_115791.2). A similar pattern was observed inHEK293 transiently expressing CARD11. These bands are not observed in thenon-transfected HEK293.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • Target
    CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))
    Andere Bezeichnung
    CARD11 / CARMA1 (CARD11 Produkte)
    Synonyme
    BENTA antikoerper, BIMP3 antikoerper, CARMA1 antikoerper, PPBL antikoerper, 0610008L17Rik antikoerper, 2410011D02Rik antikoerper, CARD11 antikoerper, LOC100232755 antikoerper, caspase recruitment domain family member 11 antikoerper, caspase recruitment domain family, member 11 antikoerper, caspase recruitment domain-containing protein 11 antikoerper, CARD11 antikoerper, Card11 antikoerper, LOC100550812 antikoerper, card11 antikoerper
    Hintergrund
    CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11
    Gen-ID
    84433
    NCBI Accession
    NP_115791
    UniProt
    Q9BXL7
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, BCR Signaling
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