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DKK2 Antikörper (C-Term)

DKK2 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh) WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374181
  • Target Alle DKK2 Antikörper anzeigen
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Bindungsspezifität
    • 10
    • 8
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 60
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Rind (Kuh)
    Wirt
    • 56
    • 3
    • 1
    Ziege
    Klonalität
    • 57
    • 3
    Polyklonal
    Konjugat
    • 28
    • 9
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DKK2 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 33
    • 31
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody detects Dickkopf-2 at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Rat, Canine, Bovine.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography
    Immunogen
    Peptide with sequence ATYSSKARLHVCQKI, from the C Terminus of the protein sequence Genename: DKK2
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  • Applikationshinweise
    Peptide ELISA: 1/8000. Western blot: 1 - 3 μg/mL. Approx 28 kDa band observed in Human Heart lysate (calculatedMW of 28.8 kDa according to NP_055236).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Andere Bezeichnung
    Dickkopf-2 (DKK2) (DKK2 Produkte)
    Synonyme
    DKK-2 antikoerper, Dkk4 antikoerper, zgc:171574 antikoerper, dickkopf WNT signaling pathway inhibitor 2 antikoerper, DKK2 antikoerper, Dkk2 antikoerper, dkk2 antikoerper
    Hintergrund
    Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.Synonyms: Dickkopf-related protein 2, Dkk-2
    Gen-ID
    27123
    NCBI Accession
    NP_055236
    UniProt
    Q9UBU2
    Pathways
    WNT Signalweg
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