MTA1 Antikörper (C-Term, Internal Region)

Produktnummer ABIN374108

Produktdetails anti-MTA1 Antikörper

Target: MTA1 (Metastasis Associated 1 (MTA1))

Bindungsspezifität: C-Term, Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser MTA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: C-PGDVFYMPKE

Spezifität: This antibody detects MTA1 (Internal).

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from the internal region (near the C Terminus) of the protein sequence according to NP_004680.1 Genename: MTA1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 16000. Western blot: 0.03-0.1 μg/mL. Approx 75 kDa band observed in Human Placenta lysates(calculated MW of 80.5 kDa according to NP_004680.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Details zu MTA1

Target: MTA1 (Metastasis Associated 1 (MTA1))

Andere Bezeichnung: MTA1 (MTA1 Produkte)

Synonyme: Tex22 antikoerper, metastasis associated 1 antikoerper, metastasis associated 1 L homeolog antikoerper, MTA1 antikoerper, Mta1 antikoerper, mta1.L antikoerper

Hintergrund: MTA1 was identified in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this protein has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70 kDa component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this protein suggests that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.Synonyms: Metastasis-associated protein MTA1

Gen-ID: 9112

NCBI Accession: NP_004680

UniProt: Q13330

Pathways: Chromatin Binding