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SOCS1 Antikörper (C-Term)

SOCS1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund WB, IHC (p), EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374072
  • Target Alle SOCS1 Antikörper anzeigen
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Bindungsspezifität
    • 15
    • 12
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 66
    • 36
    • 28
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Human, Maus, Ratte, Rind (Kuh), Hund
    Wirt
    • 63
    • 5
    • 2
    Ziege
    Klonalität
    • 66
    • 4
    Polyklonal
    Konjugat
    • 36
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SOCS1 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 23
    • 16
    • 13
    • 13
    • 11
    • 10
    • 9
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequenz
    C-VLRDYLSSFP FQI
    Spezifität
    Recognizes Suppressor Of Cytokine Signaling 1 (SOCS1) at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Rat, Canine (Dog) and Bovine.
    Species reactivity (tested):Human, Mouse.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Synthetic peptide from the C-Terminus of Human SOCS1 (NP_003736.1). Genename: SOCS1
    Top Product
    Discover our top product SOCS1 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Limit Dilution: 1/4000. Western blot: 1-3 μg/mL. In transfected HEK293 transiently expressing human SOCS1 bandsof approx.30 kDa and 20 kDa are observed. These bands are not observed in thenon-transfected HEK293. A similar pattern is observed in Mouse Spleen lysates. Thecalculated molecular size is 23.0 kDa according to Human NP_003736.1 and 23.0 kDa
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline buffer, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Andere Bezeichnung
    SOCS1 (SOCS1 Produkte)
    Synonyme
    socs1 antikoerper, zgc:91868 antikoerper, jab antikoerper, cis1 antikoerper, ssi1 antikoerper, tip3 antikoerper, cish1 antikoerper, ssi-1 antikoerper, socs-1 antikoerper, SOCS1 antikoerper, LOC100228306 antikoerper, socs1b antikoerper, CIS1 antikoerper, CISH1 antikoerper, JAB antikoerper, SOCS-1 antikoerper, SSI-1 antikoerper, SSI1 antikoerper, TIP3 antikoerper, Cish1 antikoerper, Cish7 antikoerper, Socs-1 antikoerper, suppressor of cytokine signaling 1a antikoerper, suppressor of cytokine signaling 1 antikoerper, suppressor of cytokine signaling 1 L homeolog antikoerper, socs1a antikoerper, socs1 antikoerper, SOCS1 antikoerper, socs1.L antikoerper, Socs1 antikoerper
    Hintergrund
    SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
    Gen-ID
    8651
    NCBI Accession
    NP_003736
    UniProt
    O15524
    Pathways
    JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus
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