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Axin Antikörper (C-Term)

AXIN1 Reaktivität: Human, Maus, Ratte, Hund IHC (p), EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN372934
  • Target Alle Axin (AXIN1) Antikörper anzeigen
    Axin (AXIN1) (Axin 1 (AXIN1))
    Bindungsspezifität
    • 15
    • 15
    • 15
    • 14
    • 11
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 89
    • 53
    • 32
    • 2
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 115
    • 7
    • 1
    Ziege
    Klonalität
    • 116
    • 7
    Polyklonal
    Konjugat
    • 37
    • 11
    • 10
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Axin Antikörper ist unkonjugiert
    Applikation
    • 101
    • 49
    • 39
    • 39
    • 31
    • 11
    • 9
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequenz
    c-FEEKIIGKVE KVD
    Spezifität
    This antibody recognizes Axin 1 (AXIN1).
    Kreuzreaktivität (Details)
    Species reactivity (expected):Canine (Dog), Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide from C-terminus of Human AXIN1.
    Isotyp
    IgG
    Top Product
    Discover our top product AXIN1 Primärantikörper
  • Applikationshinweise
    ELISA: 1/28000. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris-Saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    Axin (AXIN1) (Axin 1 (AXIN1))
    Andere Bezeichnung
    Axin-1 (AXIN1 Produkte)
    Synonyme
    AXIN1 antikoerper, axin antikoerper, fused antikoerper, xAxin antikoerper, LOC100226467 antikoerper, AXIN antikoerper, PPP1R49 antikoerper, AI316800 antikoerper, Axin antikoerper, Fu antikoerper, Kb antikoerper, Ki antikoerper, kinky antikoerper, knobbly antikoerper, AXIN1-RGS antikoerper, wu:fi22e03 antikoerper, wu:fj14c08 antikoerper, wu:fk11b03 antikoerper, zgc:109872 antikoerper, axin 1 antikoerper, axin 1 S homeolog antikoerper, axin 1 L homeolog antikoerper, AXIN1 antikoerper, axin1.S antikoerper, axin1.L antikoerper, Axin1 antikoerper, axin1 antikoerper
    Hintergrund
    Axin-1 (Axis inhibition protein 1) and Axin-2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin-1 interacts with APC, GSK3-beta, Dvl and beta-Catenin and promotes the GSK3-beta-mediated phosphorylation and subsequent degradation of beta-Catenin (1,2). Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling (3,4). In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) (5). Axin2 (also known as Conductin or Axil) can functionally substitute Axin1 in mice (6). Axin-2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop (7-9).Synonyms: AXIN, AXIN1, Axis inhibition protein 1
    Gen-ID
    8312
    NCBI Accession
    NP_003493
    UniProt
    O15169
    Pathways
    WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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