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PIK3R1 Antikörper (pTyr467)

PI3K p85a Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN372742
  • Target Alle PIK3R1 (PI3K p85a) Antikörper anzeigen
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    Bindungsspezifität
    • 18
    • 15
    • 15
    • 15
    • 13
    • 13
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr467
    Reaktivität
    • 141
    • 97
    • 72
    • 18
    • 17
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 124
    • 33
    Kaninchen
    Klonalität
    • 108
    • 49
    Polyklonal
    Konjugat
    • 81
    • 11
    • 11
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PIK3R1 Antikörper ist unkonjugiert
    Applikation
    • 123
    • 60
    • 41
    • 28
    • 25
    • 18
    • 17
    • 16
    • 15
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody detects endogenous levels of total PI3K P85 only when phosphorylated at Tyrosine 467.
    Aufreinigung
    Affinity Chromatography using epitope-specific phosphopeptide.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human PI3K P85 around the phosphorylation site of Tyrosine 467 (L-YP-E-E-Y).
    Top Product
    Discover our top product PI3K p85a Primärantikörper
  • Applikationshinweise
    Suitable for use in in Western blot (1/500-1/1000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    Andere Bezeichnung
    PIK3R1 / GRB1 (PI3K p85a Produkte)
    Synonyme
    PI3CG antikoerper, PI3K antikoerper, PI3Kgamma antikoerper, PIK3 antikoerper, AGM7 antikoerper, GRB1 antikoerper, p85 antikoerper, p85-ALPHA antikoerper, PI3KA antikoerper, AA414921 antikoerper, C530050K14 antikoerper, p50alpha antikoerper, p55alpha antikoerper, p85alpha antikoerper, wu:fb65b05 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antikoerper, phosphoinositide-3-kinase regulatory subunit 1 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antikoerper, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antikoerper, PIK3CG antikoerper, PIK3R1 antikoerper, Pik3r1 antikoerper, Pik3cb antikoerper, pik3r1 antikoerper
    Hintergrund
    The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.Synonyms: PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha
    Gen-ID
    5295
    NCBI Accession
    NP_852556
    UniProt
    P27986
    Pathways
    T-Zell Rezeptor Signalweg, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effekt
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