UCHL1 Antikörper

Produktnummer ABIN372739

Produktdetails anti-UCHL1 Antikörper

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Säugetier

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser UCHL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Specific for the the ~24 kDa UCHL1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mamalia.
Species reactivity (tested):Bovine, Human, Mouse and Rat.

Aufreinigung: Ig Fraction

Immunogen: Recombinant full length human UCHL1 purified from E. coli.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western blotting: 1/2,500. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Andere Bezeichnung: UCHL1 / PGP9.5 (UCHL1 Produkte)

Synonyme: PARK5 antikoerper, PGP 9.5 antikoerper, PGP9.5 antikoerper, PGP95 antikoerper, Uch-L1 antikoerper, UCH-L1 antikoerper, UCHL1 antikoerper, cb358 antikoerper, wu:fc55h08 antikoerper, park5 antikoerper, pgp9.5 antikoerper, uch-l1 antikoerper, MGC132191 antikoerper, uchl1 antikoerper, AW822034 antikoerper, C88048 antikoerper, R75593 antikoerper, UCHL-1 antikoerper, gad antikoerper, ubiquitin C-terminal hydrolase L1 antikoerper, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) antikoerper, ubiquitin C-terminal hydrolase L1 L homeolog antikoerper, ubiquitin carboxyl-terminal esterase L1 antikoerper, ubiquitin carboxy-terminal hydrolase L1 antikoerper, UCHL1 antikoerper, uchl1 antikoerper, uchl1.L antikoerper, LOC100304750 antikoerper, Uchl1 antikoerper

Hintergrund: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1

Gen-ID: 7345

NCBI Accession: NP_004172

UniProt: P09936

Pathways: Feeding Behaviour