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MAP2K5 Antikörper (pSer311, pThr315)

MAP2K5 Reaktivität: Human, Maus, Ratte, Hund, Huhn, Rind (Kuh), Zebrafisch (Danio rerio), Xenopus laevis, Non-Human Primate WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN372667
  • Target Alle MAP2K5 Antikörper anzeigen
    MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
    Bindungsspezifität
    • 28
    • 28
    • 16
    • 15
    • 15
    • 15
    • 9
    • 9
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer311, pThr315
    Reaktivität
    • 131
    • 58
    • 54
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn, Rind (Kuh), Zebrafisch (Danio rerio), Xenopus laevis, Non-Human Primate
    Wirt
    • 142
    • 7
    Kaninchen
    Klonalität
    • 133
    • 16
    Polyklonal
    Konjugat
    • 45
    • 11
    • 10
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    Dieser MAP2K5 Antikörper ist unkonjugiert
    Applikation
    • 114
    • 66
    • 65
    • 50
    • 19
    • 15
    • 14
    • 12
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody is specific for the ~49k MEK5 protein phosphorylated at Ser311, Thr315. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Human, Chicken, Bovine, Canine, non-Human Primates, Xenopus, and Zebrafish.
    Species reactivity (tested):Rat.
    Aufreinigung
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser311, Thr315 of MEK5.
    Isotyp
    IgG
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  • Applikationshinweise
    Western blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Target
    MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
    Andere Bezeichnung
    MAP2K5 (MAP2K5 Produkte)
    Synonyme
    Mek5 antikoerper, HsT17454 antikoerper, MAPKK5 antikoerper, MEK5 antikoerper, PRKMK5 antikoerper, AI324775 antikoerper, AI428457 antikoerper, Mapkk5 antikoerper, Prkmk5 antikoerper, fb73f02 antikoerper, wu:fb73f02 antikoerper, zgc:172137 antikoerper, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 antikoerper, ATMAP2K_ALPHA antikoerper, ATMEK5 antikoerper, ATMKK5 antikoerper, MAP KINASE KINASE 5 antikoerper, MAP kinase kinase 5 antikoerper, MAP2K_A antikoerper, mitogen activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 L homeolog antikoerper, MAP kinase kinase 5 antikoerper, Map2k5 antikoerper, MAP2K5 antikoerper, map2k5 antikoerper, map2k5.L antikoerper, MKK5 antikoerper
    Hintergrund
    MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).Synonyms: Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
    Gen-ID
    29568
    NCBI Accession
    NP_001029159
    UniProt
    Q62862
    Pathways
    MAPK Signalweg, Neurotrophin Signalübertragung
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