Chemokine (C-C Motif) Receptor 1 (CCR1) Antikörper

Antigen: Chemokine (C-C Motif) Receptor 1 (CCR1)

Synonyme: CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN372407

Produktbeschreibung

Produktmerkmale: Synonyms: C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1,HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alphaReceptor, RANTES-R

Weitere Bezeichnung: CD191 / CCR1

Swiss-Prot: P32246

Immunogen: A synthetic peptide of human CCR1 protein.

Kreuzreaktivität: Human, Maus

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: This gene encodes a member of the beta chemokine receptor family, which is predicted tobe a seven transmembrane protein similar to G protein-coupled receptors. The ligands ofthis receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated onactivation normal T expressed and secreted protein (RANTES), monocyte chemoattractantprotein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and theirreceptors mediated signal transduction are critical for the recruitment of effector immunecells to the site of inflammation. Knockout studies of the mouse homolog suggested theroles of this gene in host protection from inflammatory response, and susceptibility tovirus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2,CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Spezifität: This antibody recognizes C-C Chemokine Receptor 1 (CCR1/CD191). Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse.

Anwendungen

Applikationshinweise: Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western blot: 1-3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 0.5 mg/ml

Reinigung: Aff - Purified

Buffer: PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide aspreservative.

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Chemokine, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar