Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) (N-Term) Antikörper

Antigen: Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1)

Synonyme: NCX1, FLJ37694, FLJ43417, MGC119581, DKFZp779F0871, Ncx1, AI852629, AV344025, MGC90693, D930008O12Rik, Ncx, SLC8A1, ncx1n, DKFZp469I106

Epitope: N-Term

Klonalität: Monoklonal (6H2)

Wirt: Maus

Reaktivität: Säugetiere

Applikation: Western Blot (WB)

Produktnummer: ABIN371842

Produktbeschreibung

Produktmerkmale: Synonyms: CNC, Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1

Weitere Bezeichnung: SLC8A1 / NCX1

Swiss-Prot: P32418

Immunogen: Fusion protein from the N-terminus of rabbit renal Na+/Ca2+ exchanger.

Kreuzreaktivität: Säugetiere

Isotyp: IgG2b  (Passende Sekundärantikörper)

Klon: 6H2

Beschreibung: Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance iscritical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+(NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+gradient across the membrane. In mammals, at least 5 distinct genes code for theexchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family(NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays amajor role in excitation-contraction coupling (Matsuoka et al. , 1993). NACX-1 may also be atarget for protection of the heart and brain from ischemia and reperfusion injury (Hagiharaet al. , 2005, Bano et al. , 2005, Choi, 2005).

Spezifität: This antibody is specific for the ~120k and 160k Sodium/Calcium Exchanger 1 protein. Species Reactivity: Tested: most Mammals.

Anwendungen

Applikationshinweise: Western Blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Aff - Purified

Buffer: 5 mM Ammonium bicarbonate.Reconstitution: Restore in 50 µl PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mMKH2PO4, pH 7.4) before use.

Lagerung: Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar