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CBL Antikörper (AA 698-702)

CBL Reaktivität: Human IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN363123
  • Target Alle CBL Antikörper anzeigen
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Bindungsspezifität
    • 30
    • 29
    • 28
    • 17
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 698-702
    Reaktivität
    • 179
    • 80
    • 71
    • 4
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 152
    • 25
    • 3
    • 1
    Kaninchen
    Klonalität
    • 143
    • 38
    Polyklonal
    Konjugat
    • 80
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Dieser CBL Antikörper ist unkonjugiert
    Applikation
    • 85
    • 52
    • 52
    • 49
    • 34
    • 27
    • 21
    • 17
    • 12
    • 11
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Spezifität
    The antibody detects endogenous level of total c-Cbl protein.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen .
    Immunogen
    Peptide sequence around AA 698-702 (T-E-Y-M-T) derived from Human c-Cbl. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotyp
    IgG
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  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Andere Bezeichnung
    c-Cbl (CBL Produkte)
    Synonyme
    4732447J05Rik antikoerper, Cbl-2 antikoerper, c-Cbl antikoerper, cbl antikoerper, C-CBL antikoerper, CBL2 antikoerper, FRA11B antikoerper, NSLL antikoerper, RNF55 antikoerper, c-cbl-like antikoerper, RGD1561386 antikoerper, Casitas B-lineage lymphoma antikoerper, Cbl proto-oncogene antikoerper, Cbl antikoerper, CBL antikoerper
    Hintergrund
    Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
    Molekulargewicht
    120 kDa
    UniProt
    P22681
    Pathways
    T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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