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AKT 1/2/3 Antikörper (AA 313-317)

Reaktivität: Human, Maus, Ratte IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN363067
  • Target Alle AKT 1/2/3 Produkte
    AKT 1/2/3
    Bindungsspezifität
    • 25
    • 23
    • 23
    • 23
    • 20
    • 20
    • 18
    • 18
    • 16
    • 16
    • 16
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 313-317
    Reaktivität
    • 165
    • 153
    • 139
    • 46
    • 31
    • 28
    • 25
    • 15
    • 9
    • 6
    • 4
    • 4
    Human, Maus, Ratte
    Wirt
    • 163
    • 2
    Kaninchen
    Klonalität
    • 152
    • 13
    Polyklonal
    Konjugat
    • 42
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser AKT 1/2/3 Antikörper ist unkonjugiert
    Applikation
    • 148
    • 93
    • 92
    • 91
    • 36
    • 32
    • 29
    • 21
    • 9
    • 7
    • 6
    Immunohistochemistry (IHC)
    Spezifität
    The antibody detects endogenous level of total AKT1/AKT2/AKT3 protein.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
    Immunogen
    Peptide sequence around AA 313-317, 314-318, 310-314 (P-E-Y-L-A) derived from Human AKT1, AKT2, AKT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotyp
    IgG
  • Applikationshinweise
    Immunohistochemistry: 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    AKT 1/2/3
    Andere Bezeichnung
    AKT1/AKT2/AKT3 (AKT 1/2/3 Produkte)
    Hintergrund
    General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
    Molekulargewicht
    60 kDa
    UniProt
    Q9Y243
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