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APP Antikörper (AA 666-670)
APP
Reaktivität: Human, Maus, Ratte
WB, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-APP Antikörper
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Target
Alle APP Antikörper anzeigen
APP
(Amyloid beta (A4) Precursor Protein (APP))
Bindungsspezifität
Alle Epitope für APP Antikörper
AA 666-670
Reaktivität
Alle Reaktivitäten für APP Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für APP Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für APP Antikörper
Polyklonal
Konjugat
Alle Konjugate für APP Antikörper
Dieser APP Antikörper ist unkonjugiert
Applikation
Alle Applikationen für APP Antikörper
Western Blotting (WB), Immunofluorescence (IF)
Spezifität
The antibody detects endogenous level of total APP protein.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Immunogen
Peptide sequence around AA 666-670 (A-V-T-P-E ) derived from Human APP. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
Western blotting: 1:500-1:1000 Immunofluorescence: 1:100-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Details zu APP
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Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Andere Bezeichnung
APP (APP Produkte )
Synonyme
AAA antikoerper, ABETA antikoerper, ABPP antikoerper, AD1 antikoerper, APPI antikoerper, CTFgamma antikoerper, CVAP antikoerper, PN-II antikoerper, PN2 antikoerper, aaa antikoerper, abeta antikoerper, abpp antikoerper, ad1 antikoerper, appi antikoerper, ctfgamma antikoerper, cvap antikoerper, pn2 antikoerper, APP antikoerper, APP-like antikoerper, APPL antikoerper, Abeta antikoerper, BcDNA:GH04413 antikoerper, CG7727 antikoerper, Dmel\\CG7727 antikoerper, EG:65F1.5 antikoerper, appl antikoerper, Abpp antikoerper, Adap antikoerper, Ag antikoerper, Cvap antikoerper, E030013M08Rik antikoerper, betaApp antikoerper, app antikoerper, wu:fj34d10 antikoerper, wu:fk65e12 antikoerper, zgc:85740 antikoerper, amyloid beta precursor protein antikoerper, amyloid beta (A4) precursor protein antikoerper, beta amyloid protein precursor-like antikoerper, amyloid beta (A4) precursor protein a antikoerper, amyloid beta precursor protein L homeolog antikoerper, APP antikoerper, app antikoerper, Appl antikoerper, App antikoerper, appa antikoerper, app.L antikoerper
Hintergrund
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Molekulargewicht
100-140 kDa
NCBI Accession
NP_000475
UniProt
P05067
Pathways
Caspase Kaskade in der Apoptose , EGFR Signaling Pathway , Transition Metal Ion Homeostasis , Skeletal Muscle Fiber Development , Toll-Like Receptors Cascades , Feeding Behaviour
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