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p53 Antikörper (AA 4-8)

TP53 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN362642
  • Target Alle p53 (TP53) Antikörper anzeigen
    p53 (TP53) (Tumor Protein P53 (TP53))
    Bindungsspezifität
    • 51
    • 41
    • 40
    • 39
    • 32
    • 30
    • 28
    • 25
    • 24
    • 24
    • 23
    • 20
    • 20
    • 20
    • 18
    • 18
    • 16
    • 16
    • 14
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    AA 4-8
    Reaktivität
    • 900
    • 272
    • 223
    • 113
    • 48
    • 35
    • 33
    • 19
    • 10
    • 8
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 677
    • 239
    • 6
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 611
    • 314
    • 1
    Polyklonal
    Konjugat
    • 518
    • 49
    • 40
    • 26
    • 25
    • 25
    • 24
    • 24
    • 23
    • 22
    • 22
    • 13
    • 13
    • 13
    • 13
    • 13
    • 13
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser p53 Antikörper ist unkonjugiert
    Applikation
    • 725
    • 336
    • 257
    • 217
    • 210
    • 151
    • 129
    • 124
    • 119
    • 66
    • 61
    • 35
    • 20
    • 17
    • 13
    • 12
    • 12
    • 10
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous level of total p53 protein.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Peptide sequence around AA 4-8 (P-Q-S-D-P) derived from Human p53. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotyp
    IgG
    Top Product
    Discover our top product TP53 Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Ji, Ding, Hawke, Xing, Jiang, Mills, Lu: "AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis." in: EMBO reports, Vol. 13, Issue 6, pp. 554-60, (2012) (PubMed).

    Gao, Zhai, Guan, Zheng: "Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21." in: Oncology letters, Vol. 2, Issue 1, pp. 123-128, (2012) (PubMed).

  • Target
    p53 (TP53) (Tumor Protein P53 (TP53))
    Andere Bezeichnung
    p53 (TP53 Produkte)
    Synonyme
    BCC7 antikoerper, LFS1 antikoerper, P53 antikoerper, TRP53 antikoerper, p53 antikoerper, Trp53 antikoerper, brp53 antikoerper, drp53 antikoerper, etID22686.5 antikoerper, fb40d06 antikoerper, wu:fb40d06 antikoerper, zgc:111919 antikoerper, Tp53 antikoerper, bbl antikoerper, bfy antikoerper, bhy antikoerper, p44 antikoerper, tp53 antikoerper, Xp53 antikoerper, TP53 antikoerper, tumor protein p53 antikoerper, cellular tumor antigen p53 antikoerper, transformation related protein 53 antikoerper, tumor protein p53 L homeolog antikoerper, TP53 antikoerper, CpipJ_CPIJ002758 antikoerper, Tp53 antikoerper, tp53 antikoerper, Trp53 antikoerper, tp53.L antikoerper
    Hintergrund
    P53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
    Molekulargewicht
    53 kDa
    NCBI Accession
    NP_000537
    UniProt
    P04637
    Pathways
    p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
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