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PRKDC Antikörper (pThr2609)

PRKDC Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN362178
  • Target Alle PRKDC Antikörper anzeigen
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Bindungsspezifität
    • 26
    • 13
    • 12
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr2609
    Reaktivität
    • 163
    • 91
    • 49
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 154
    • 22
    • 3
    • 2
    Kaninchen
    Klonalität
    • 149
    • 32
    Polyklonal
    Konjugat
    • 97
    • 11
    • 11
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser PRKDC Antikörper ist unkonjugiert
    Applikation
    • 85
    • 70
    • 58
    • 36
    • 34
    • 28
    • 27
    • 24
    • 15
    • 13
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous level of DNA PKcs only when phosphorylated at threonine 2609.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pThr2609 (V-E-T (p) -Q-A) derived from Human DNA-PK. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotyp
    IgG
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    Discover our top product PRKDC Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Andere Bezeichnung
    DNA PKcs (PRKDC Produkte)
    Synonyme
    DNA-PKcs antikoerper, DNAPK antikoerper, DNPK1 antikoerper, HYRC antikoerper, HYRC1 antikoerper, XRCC7 antikoerper, p350 antikoerper, DNA-PKCS antikoerper, dna-pkcs antikoerper, dnapk antikoerper, dnpk1 antikoerper, hyrc antikoerper, hyrc1 antikoerper, prkdc-A antikoerper, xrcc7 antikoerper, PRKDC antikoerper, AI326420 antikoerper, AU019811 antikoerper, DNAPDcs antikoerper, DOXNPH antikoerper, dxnph antikoerper, p460 antikoerper, scid antikoerper, slip antikoerper, protein kinase, DNA-activated, catalytic polypeptide antikoerper, protein kinase, DNA-activated, catalytic polypeptide L homeolog antikoerper, DNA-dependent protein kinase catalytic subunit antikoerper, protein kinase, DNA activated, catalytic polypeptide antikoerper, PRKDC antikoerper, prkdc.L antikoerper, LOC100633457 antikoerper, Prkdc antikoerper
    Hintergrund
    The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties
    Molekulargewicht
    450 kDa
    NCBI Accession
    NP_001075
    UniProt
    P78527
    Pathways
    DNA Reparatur, Production of Molecular Mediator of Immune Response
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