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ErbB2/Her2 Antikörper (pTyr1248)

ErbB2/Her2 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN362024
  • Target Alle ErbB2/Her2 Antikörper anzeigen
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Bindungsspezifität
    • 32
    • 29
    • 27
    • 26
    • 25
    • 23
    • 23
    • 21
    • 18
    • 16
    • 15
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pTyr1248
    Reaktivität
    • 518
    • 187
    • 164
    • 34
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 409
    • 156
    • 11
    • 5
    • 3
    • 3
    Kaninchen
    Klonalität
    • 412
    • 172
    • 2
    Polyklonal
    Konjugat
    • 269
    • 46
    • 38
    • 29
    • 25
    • 24
    • 17
    • 17
    • 16
    • 16
    • 15
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser ErbB2/Her2 Antikörper ist unkonjugiert
    Applikation
    • 300
    • 229
    • 139
    • 104
    • 95
    • 93
    • 92
    • 80
    • 67
    • 53
    • 29
    • 21
    • 12
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Spezifität
    The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pTyr1248 (P-E-Y (p) -L-G) derived from Human HER2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotyp
    IgG
    Top Product
    Discover our top product ErbB2/Her2 Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Yuan, Qian, Shi, Lu, Li, Hu, Yu, Shen, Guo: "HER2-dependent MMP-7 expression is mediated by activated STAT3." in: Cellular signalling, Vol. 20, Issue 7, pp. 1284-91, (2008) (PubMed).

  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Andere Bezeichnung
    HER2 (ErbB2/Her2 Produkte)
    Synonyme
    CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper
    Hintergrund
    Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.
    Molekulargewicht
    185 kDa
    NCBI Accession
    NP_001005
    UniProt
    P04626
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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