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FAK Antikörper (pTyr861)

PTK2 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361988
  • Target Alle FAK (PTK2) Antikörper anzeigen
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Bindungsspezifität
    • 41
    • 29
    • 27
    • 25
    • 23
    • 23
    • 21
    • 18
    • 16
    • 16
    • 13
    • 11
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr861
    Reaktivität
    • 335
    • 290
    • 225
    • 24
    • 21
    • 18
    • 17
    • 14
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 338
    • 27
    • 3
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 328
    • 44
    Polyklonal
    Konjugat
    • 185
    • 19
    • 16
    • 14
    • 14
    • 13
    • 13
    • 13
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 1
    Dieser FAK Antikörper ist unkonjugiert
    Applikation
    • 305
    • 126
    • 122
    • 121
    • 108
    • 75
    • 70
    • 52
    • 32
    • 31
    • 25
    • 6
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous level of FAK only when phosphorylated at tyrosine 861.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pTyr861 (H-I-Y (p) -Q-P) derived from Human FAK. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotyp
    IgG
    Top Product
    Discover our top product PTK2 Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Kanehira, Kikuchi, Ohkouchi, Shibahara, Tode, Santoso, Daito, Ohta, Tamada, Nukiwa: "Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells." in: PLoS ONE, Vol. 7, Issue 2, pp. e32185, (2012) (PubMed).

    Sheng, Song, Zheng, Zhou, Lu, Zhao, Zhang, Gong: "Abnormal cleavage of APP impairs its functions in cell adhesion and migration." in: Neuroscience letters, Vol. 450, Issue 3, pp. 327-31, (2009) (PubMed).

    Zheng, Wei, Wang, Gong, Zhang: "Surface characterization and cytocompatibility of three chitosan/polycation composite membranes for guided bone regeneration." in: Journal of biomaterials applications, Vol. 24, Issue 3, pp. 209-29, (2009) (PubMed).

    Wu, Zhu, Shi, Zhang, Ma, Yu: "Zoledronate inhibits the proliferation, adhesion and migration of vascular smooth muscle cells." in: European journal of pharmacology, Vol. 602, Issue 1, pp. 124-31, (2008) (PubMed).

  • Target
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Andere Bezeichnung
    FAK (PTK2 Produkte)
    Synonyme
    FADK antikoerper, FAK antikoerper, FAK1 antikoerper, FRNK antikoerper, PPP1R71 antikoerper, p125FAK antikoerper, pp125FAK antikoerper, PTK2 antikoerper, Fadk antikoerper, mKIAA4203 antikoerper, fak antikoerper, fak1a antikoerper, ptk2 antikoerper, ptk2a antikoerper, wu:fa18c04 antikoerper, zgc:66114 antikoerper, CG10023 antikoerper, CT28129 antikoerper, DFAK antikoerper, DFak antikoerper, DFak56 antikoerper, Dfak antikoerper, Dfak56 antikoerper, DmFAK antikoerper, Dmel\\CG10023 antikoerper, Fak56 antikoerper, Fak56D antikoerper, fak56 antikoerper, protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2 L homeolog antikoerper, PTK2 protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2ab antikoerper, Focal adhesion kinase antikoerper, PTK2 antikoerper, ptk2.L antikoerper, Ptk2 antikoerper, ptk2ab antikoerper, Fak antikoerper
    Hintergrund
    Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
    Molekulargewicht
    125 kDa
    UniProt
    Q05397
    Pathways
    Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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