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Nibrin Antikörper (pSer343)

NBN Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361984
  • Target Alle Nibrin (NBN) Antikörper anzeigen
    Nibrin (NBN)
    Bindungsspezifität
    • 37
    • 15
    • 12
    • 8
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer343
    Reaktivität
    • 102
    • 62
    • 36
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 121
    • 15
    Kaninchen
    Klonalität
    • 109
    • 27
    Polyklonal
    Konjugat
    • 70
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Nibrin Antikörper ist unkonjugiert
    Applikation
    • 107
    • 45
    • 30
    • 27
    • 26
    • 26
    • 26
    • 18
    • 12
    • 11
    • 6
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pSer343 (S-L-S (p) -Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotyp
    IgG
    Top Product
    Discover our top product NBN Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Drissi, Wu, Hu, Bockhold, Dome: "Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells." in: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 12, pp. 1973-81, (2011) (PubMed).

    Carrillo, Schneider, Taylor, Srinivasan, Kapoor, Bhatia: "Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia." in: Cerebellum (London, England), Vol. 8, Issue 1, pp. 22-7, (2009) (PubMed).

  • Target
    Nibrin (NBN)
    Andere Bezeichnung
    p95/NBS1 (NBN Produkte)
    Synonyme
    NBN antikoerper, AT-V1 antikoerper, AT-V2 antikoerper, ATV antikoerper, NBS antikoerper, NBS1 antikoerper, P95 antikoerper, Nbs1 antikoerper, im:6911679 antikoerper, zgc:194152 antikoerper, nibrin antikoerper, NBN antikoerper, nbn antikoerper, Nbn antikoerper
    Hintergrund
    Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
    Molekulargewicht
    95 kDa
    NCBI Accession
    NP_002476
    UniProt
    O60934
    Pathways
    DNA Reparatur, Production of Molecular Mediator of Immune Response
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