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HSP90 Antikörper

HSP90 Reaktivität: Human WB, IP, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361823
  • Target Alle HSP90 Antikörper anzeigen
    HSP90 (Heat Shock Protein 90 (HSP90))
    Reaktivität
    • 121
    • 63
    • 63
    • 33
    • 26
    • 21
    • 20
    • 20
    • 12
    • 10
    • 10
    • 10
    • 10
    • 9
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 98
    • 65
    • 3
    • 1
    Kaninchen
    Klonalität
    • 101
    • 66
    Polyklonal
    Konjugat
    • 58
    • 12
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 9
    • 9
    • 7
    • 4
    • 4
    Dieser HSP90 Antikörper ist unkonjugiert
    Applikation
    • 138
    • 104
    • 92
    • 69
    • 61
    • 57
    • 33
    • 20
    • 13
    • 10
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~90 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    Full length protein HSP90
    Top Product
    Discover our top product HSP90 Primärantikörper
  • Applikationshinweise
    • WB (1:500)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    A 1:500 dilution of ABIN361822 was sufficient for detection of 0.2 mg of purified HSP90 by ECL immunoblot analysis.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Bacci, Aiello, Ripoli, Loria, Pugliese, Pierconti, Rotili, Strigari, Pinto, Bassi, Mai, Grassi, Pontecorvi, Falcioni, Farsetti, Nanni: "H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer." in: International journal of molecular sciences, Vol. 20, Issue 16, (2019) (PubMed).

    Re, Colussi, Nanni, Aiello, Bacci, Grassi, Pontecorvi, Farsetti: "Nucleoporin 153 regulates estrogen-dependent nuclear translocation of endothelial nitric oxide synthase and estrogen receptor beta in prostate cancer." in: Oncotarget, Vol. 9, Issue 46, pp. 27985-27997, (2018) (PubMed).

    Zhang, Pruitt, Tran, Du Bois, Zhang, Patel, Hoover, Simpson, Simmons, Gary, Snapper, Casellas, Mock: "B cell-specific deficiencies in mTOR limit humoral immune responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 4, pp. 1692-703, (2013) (PubMed).

    Verheyen, Peeraer, Nuydens, Dhondt, Poesen, Pintelon, Daniels, Timmermans, Meert, Carmeliet, Lambrechts: "Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy." in: Brain : a journal of neurology, Vol. 135, Issue Pt 9, pp. 2629-41, (2012) (PubMed).

    Wagatsuma, Shiozuka, Kotake, Takayuki, Yusuke, Mabuchi, Matsuda, Yamada: "Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells." in: Molecular and cellular biochemistry, Vol. 358, Issue 1-2, pp. 265-80, (2011) (PubMed).

  • Target
    HSP90 (Heat Shock Protein 90 (HSP90))
    Andere Bezeichnung
    HSP90 (HSP90 Produkte)
    Synonyme
    EL52 antikoerper, HSP86 antikoerper, HSP89A antikoerper, HSP90A antikoerper, HSP90N antikoerper, HSPC1 antikoerper, HSPCA antikoerper, HSPCAL1 antikoerper, HSPCAL4 antikoerper, HSPN antikoerper, Hsp89 antikoerper, Hsp90 antikoerper, LAP2 antikoerper, git10 antikoerper, swo1 antikoerper, HSP90 antikoerper, htpG antikoerper, SCBAC25F8.08 antikoerper, 23.m06066 antikoerper, 17.m07646 antikoerper, HSP90-1 antikoerper, 143198_at antikoerper, 83 antikoerper, 83K HSP antikoerper, DMHSP82 antikoerper, E(sev)3A antikoerper, E(sina)2 antikoerper, HSP82 antikoerper, HSP83 antikoerper, ORF1 antikoerper, Su(Raf)3A antikoerper, anon-EST:Liang-2.53 antikoerper, anon-WO0068693 antikoerper, anon-WO0140519.209 antikoerper, clone 2.53 antikoerper, en(lz)3C/4C antikoerper, hsp84 antikoerper, l(3)j5C2 antikoerper, ms(3)08445 antikoerper, stc antikoerper, DmelCG1242 antikoerper, CG1242 antikoerper, Hsp86 antikoerper, Hspca antikoerper, 86kDa antikoerper, 89kDa antikoerper, AL024080 antikoerper, AL024147 antikoerper, Hsp86-1 antikoerper, hsp4 antikoerper, hsp86 antikoerper, hsp89 antikoerper, hsp90 antikoerper, hsp90a antikoerper, hspc1 antikoerper, hspca antikoerper, hspn antikoerper, lap2 antikoerper, Hsp90alpha antikoerper, heat shock protein 90 alpha family class A member 1 antikoerper, heat shock protein Hsp90 antikoerper, Hsp90 chaperone antikoerper, Heat shock protein 90 antikoerper, heat shock protein 90 antikoerper, chaperone protein HtpG antikoerper, molecular chaperone HtpG antikoerper, Heat Shock Protein 90 antikoerper, uncharacterized LOC100384473 antikoerper, Heat shock protein 83 antikoerper, heat shock protein 90, alpha (cytosolic), class A member 1 antikoerper, heat shock protein 90 alpha family class B member 1 antikoerper, heat shock protein 90kDa alpha family class A member 1 L homeolog antikoerper, heat shock protein HSP 90-alpha antikoerper, HSP90AA1 antikoerper, hsp90 antikoerper, HSP90 antikoerper, daf-21 antikoerper, htpG antikoerper, SCO7516 antikoerper, MAP_RS10510 antikoerper, TP04_0646 antikoerper, TP01_0934 antikoerper, APH_RS03525 antikoerper, GbCGDNIH1_0315 antikoerper, MAV_2118 antikoerper, HSP90C antikoerper, BBOV_IV008400 antikoerper, BBOV_III007380 antikoerper, ACICU_00312 antikoerper, ECL_01244 antikoerper, YE105_C1172 antikoerper, pco153543(105) antikoerper, Hsp83 antikoerper, Hsp90aa1 antikoerper, HSP90AB1 antikoerper, hsp90aa1.1.L antikoerper, LOC108698781 antikoerper
    Hintergrund
    HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1-2 % of cytosolic protein). It carries out a number of housekeeping functions - including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
    Gen-ID
    3326
    NCBI Accession
    NP_031381
    UniProt
    P08238
    Pathways
    M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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