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HSP70 Antikörper

HSP70 Reaktivität: Human WB, ELISA, IHC, IF, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361820
  • Target Alle HSP70 Antikörper anzeigen
    HSP70 (Heat Shock Protein 70 (HSP70))
    Reaktivität
    • 323
    • 199
    • 165
    • 71
    • 62
    • 53
    • 52
    • 52
    • 36
    • 33
    • 29
    • 29
    • 28
    • 23
    • 20
    • 18
    • 15
    • 13
    • 12
    • 12
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 206
    • 150
    • 13
    • 11
    • 11
    Kaninchen
    Klonalität
    • 228
    • 162
    Polyklonal
    Konjugat
    • 112
    • 31
    • 28
    • 26
    • 24
    • 20
    • 19
    • 18
    • 18
    • 18
    • 12
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser HSP70 Antikörper ist unkonjugiert
    Applikation
    • 374
    • 159
    • 142
    • 122
    • 122
    • 110
    • 101
    • 66
    • 62
    • 61
    • 41
    • 33
    • 22
    • 21
    • 21
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    Detects a ~70 kDa. May cross-react with HSC70 at lower dilutions.
    Kreuzreaktivität
    Beluga, Karpfen, Koralle, Rind (Kuh), Hund, Fisch, Meerschweinchen, Hamster, Human, Leishmania amazonensis, Affe, Maus, Schwein, Pflanzen, Ratte, Hai, Schaf
    Aufreinigung
    Peptide Affinity Purified
    Immunogen
    Recombinant Full length HSP70 Protein
    Top Product
    Discover our top product HSP70 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • IP (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    A 1:1000 dilution of ABIN361820 was sufficient for detection of HSP70 in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Woodford, Dunn, Blanden, Capriotti, Loiselle, Prodromou, Panaretou, Hughes, Smith, Ackerman, Haystead, Loh, Bourboulia, Schmidt, Marston Linehan, Bratslavsky, Mollapour: "The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding." in: Nature communications, Vol. 7, pp. 12037, (2018) (PubMed).

    Codonho, Costa, Peloso, Joazeiro, Gadelha, Giorgio: "HSP70 of Leishmania amazonensis alters resistance to different stresses and mitochondrial bioenergetics." in: Memórias do Instituto Oswaldo Cruz, (2017) (PubMed).

    Watanabe, Tsujimura, Taguchi, Tanaka: "HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis." in: Autophagy, Vol. 13, Issue 1, pp. 133-148, (2017) (PubMed).

    Silverstein, Ordanes, Wylie, Files, Milligan, Presley, Kavanagh: "Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, Issue 7, pp. 800-8, (2015) (PubMed).

  • Target
    HSP70 (Heat Shock Protein 70 (HSP70))
    Andere Bezeichnung
    HSP70 (HSP70 Produkte)
    Synonyme
    APG-2 antikoerper, HS24/P52 antikoerper, HSPH2 antikoerper, RY antikoerper, hsp70 antikoerper, hsp70RY antikoerper, CG31354 antikoerper, HSP70 antikoerper, Hsp70Bb antikoerper, hsp70B antikoerper, hsp70Bb-prime antikoerper, DmelCG5834 antikoerper, CG5834 antikoerper, HSPA1 antikoerper, HSP70B' antikoerper, HSPA6 antikoerper, ARABIDOPSIS HEAT SHOCK PROTEIN 70 antikoerper, ATHSP70 antikoerper, heat shock protein 70 antikoerper, LOC100305036 antikoerper, hsc70 antikoerper, Hsp70 antikoerper, Hsp70-1 antikoerper, Hsp70.1 antikoerper, hsp68 antikoerper, Hsp110 antikoerper, irp94 antikoerper, HSP70-2 antikoerper, HSPA1B antikoerper, HSPA2 antikoerper, hsp70-5 antikoerper, HSP70-1 antikoerper, HSP70.1 antikoerper, HSP70.2 antikoerper, heat shock protein family A (Hsp70) member 4 antikoerper, CG5834 gene product from transcript CG5834-RA antikoerper, heat shock protein 70 antikoerper, heat shock protein family A (Hsp70) member 6 antikoerper, heat shock 70kDa protein 2 antikoerper, heat shock 70 kD protein cognate antikoerper, Hsp70 family chaperone antikoerper, Heat shock protein 70 antikoerper, Heat shock protein 70, putative antikoerper, heat shock protein 1B antikoerper, heat shock protein family A member 4 antikoerper, heat shock 70kDa protein 1A antikoerper, heat shock protein 1 antikoerper, Heat Shock Protein antikoerper, heat shock cognate 70-kd protein antikoerper, Heat shock 70 kDa protein 1A antikoerper, HSPA4 antikoerper, Hsp70Bbb antikoerper, HSP70 antikoerper, HSPA6 antikoerper, HSPA2 antikoerper, PCC7424_2419 antikoerper, Isop_1041 antikoerper, CGB_C3390W antikoerper, Bacsa_1698 antikoerper, dnaK-B antikoerper, LOC100305036 antikoerper, Hspa1b antikoerper, Hspa4 antikoerper, HSPA1A antikoerper, hsp1 antikoerper, hsp-70 antikoerper, hsp70 antikoerper, LOC108348108 antikoerper
    Hintergrund
    HSP70 genes encode abundant heat-inducible 70- kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 50 % identity (1, 2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATPbinding domain displays multiple features of nucleotide binding proteins (5). All HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
    Gen-ID
    3303
    NCBI Accession
    NP_005336
    UniProt
    P0DMV8, P0DMV9
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