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CRYAB Antikörper

CRYAB Reaktivität: Human WB, ELISA, IF, ICC Wirt: Maus Monoclonal 1A7-D5 unconjugated
Produktnummer ABIN361808
  • Target Alle CRYAB Antikörper anzeigen
    CRYAB (Crystallin, alpha B (CRYAB))
    Reaktivität
    • 130
    • 97
    • 84
    • 15
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    Human
    Wirt
    • 159
    • 32
    • 2
    • 1
    Maus
    Klonalität
    • 152
    • 42
    Monoklonal
    Konjugat
    • 76
    • 11
    • 11
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser CRYAB Antikörper ist unkonjugiert
    Applikation
    • 139
    • 73
    • 66
    • 66
    • 57
    • 35
    • 33
    • 32
    • 17
    • 15
    • 11
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~20 kDa (Predicted mol. weight is ~21 kDa). Does not cross-react with αA-crystallin, βL-crystallin, βH-crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
    Kreuzreaktivität
    Rind (Kuh), Human, Schwein, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Native Alpha B Crystallin
    Klon
    1A7-D5
    Isotyp
    IgG1
    Top Product
    Discover our top product CRYAB Primärantikörper
  • Applikationshinweise
    • WB (1:2000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml of ABIN361808 was sufficient for detection of 50 ng purified alpha B crystalline by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Piccolella, Crippa, Cristofani, Rusmini, Galbiati, Cicardi, Meroni, Ferri, Morelli, Carra, Messi, Poletti: "The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells." in: Oncotarget, Vol. 8, Issue 6, pp. 10400-10415, (2018) (PubMed).

    Akkad, Corpeno, Larsson: "Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model." in: PLoS ONE, Vol. 9, Issue 4, pp. e92622, (2014) (PubMed).

    Ochala, Gustafson, Diez, Renaud, Li, Aare, Qaisar, Banduseela, Hedström, Tang, Dworkin, Ford, Nair, Perera, Gautel, Larsson: "Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms." in: The Journal of physiology, Vol. 589, Issue Pt 8, pp. 2007-26, (2011) (PubMed).

    Aare, Ochala, Norman, Radell, Eriksson, Göransson, Chen, Hoffman, Larsson: "Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model." in: Physiological genomics, Vol. 43, Issue 24, pp. 1334-50, (2011) (PubMed).

    Banduseela, Ochala, Chen, Göransson, Norman, Radell, Eriksson, Hoffman, Larsson: "Gene expression and muscle fiber function in a porcine ICU model." in: Physiological genomics, Vol. 39, Issue 3, pp. 141-59, (2009) (PubMed).

  • Target
    CRYAB (Crystallin, alpha B (CRYAB))
    Andere Bezeichnung
    Alpha B Crystallin (CRYAB Produkte)
    Synonyme
    CMD1II antikoerper, CRYA2 antikoerper, CTPP2 antikoerper, CTRCT16 antikoerper, HSPB5 antikoerper, MFM2 antikoerper, Crya-2 antikoerper, Crya2 antikoerper, HspB5 antikoerper, AACRYA antikoerper, CRYAB antikoerper, cryab antikoerper, cryab2 antikoerper, wu:fe37f08 antikoerper, zgc:91937 antikoerper, crystallin alpha B antikoerper, crystallin, alpha B antikoerper, hypothetical protein antikoerper, crystallin, alpha B, a antikoerper, crystallin, alpha B, b antikoerper, CRYAB antikoerper, Cryab antikoerper, ZK1128.7 antikoerper, cryaba antikoerper, cryabb antikoerper
    Hintergrund
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
    Gen-ID
    1410
    NCBI Accession
    NP_001876
    UniProt
    P02511
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