Discs, Large Homolog 3 (Synapse-Associated Protein 102) (Sap102) (DLG3) Antikörper

Antigen: Discs, Large Homolog 3 (Synapse-Associated Protein 102) (Sap102) (DLG3)

Klonalität: Monoklonal (S19-2)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC), Immunpräzipitation (IP)

Produktnummer: ABIN361791

Produktbeschreibung

Produktmerkmale: Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.

Weitere Bezeichnung: SAP102

Gen-ID: 58948

Swiss-Prot: Q62936

Immunogen: Fusion protein amino acids 1-120 ofd rat SAP102 (accession number Q62936)

Format: Liquid

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: S19-2

Beschreibung: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway . SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Synonyms: DLG3, MRX90, NEDLG, XLMR

Spezifität: ~105 kDa. No cross-reactivity against PSD-95, SAP97, Chapsyn-110. Species Cross-Reactivity Mouse, Rat, Human.

Sensitivität: 1µg/ml was sufficient for detection of Sap102 in 10µg of rat brain lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

Anwendungen

Applikationshinweise: WB: 1:1000 (ECL)

Konzentration: 1 mg/mL

Reinigung: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Forschungsgebiet: Neurologie, Proliferationsmarker

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

SAP102 (S19-2), Rat brain extract