KIR2.2 Antikörper

Antigen: KIR2.2

Klonalität: Monoklonal (S124B-38)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361770

Produktbeschreibung

Produktmerkmale: Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.3

Gen-ID: 117052

Swiss-Prot: Q6U7SO

Immunogen: Fusion protein amino acids 362-427 of rat Kir2.2, accession number NP_446433

Format: Liquid

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: S124B-38

Beschreibung: Kir2.2 participates in establishing action potential waveform and excitability of neuronal and muscle tissues. This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Synonyms: IRK2, KCNJ12, kcnj12x, KCNJN1, Kir2.2v, potassium inwardly rectifying channel subfamily J member 12

Spezifität: ~45kDa. No cross reactivity against Kir2.1, or Kir2.3. Species cross-reactivity: Human, Mouse, Rat.

Sensitivität: 1 µg/mL of SMC-311 was sufficient for detection of Kir2.2 in 30µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Anwendungen

Applikationshinweise: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Konzentration: 1 mg/mL

Reinigung: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Kir2 2 (S24-1), human cell line mix

Kir2.2 (S24-1), Muse backskin

Kir2.2 (S24-1), Human hippocampus

Publikationen

Publikationen: Zobel, Cho, Nguyen et al.: "Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2." in: The Journal of physiology, Vol. 550, Issue Pt 2, pp. 365-72, 2003 (PubMed).