Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) Antikörper

Antigen: Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4)

Synonyme: DFNA2, KV7.4, DFNA2A, KCNQ4, kv7.4, k(v)7.4, MGC146308

Klonalität: Monoklonal (S43-6)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB), Immunpräzipitation (IP), Immunzytochemie (ICC)

Produktnummer: ABIN361768

Produktbeschreibung

Produktmerkmale: Detects ~77kDa.

Weitere Bezeichnung: KCNQ4

Gen-ID: 9132

Swiss-Prot: P56696

Immunogen: Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696

Format: Liquid

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: S43-6

Beschreibung: Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug.
Synonyms: DFNA2, KQT like 4, Kv7.4, voltage gated potassium channel subunit Kv7.4

Spezifität: ~77kDa. Species cross-reactivity: Human, Mouse, Rat.

Sensitivität: 1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Anwendungen

Applikationshinweise: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Konzentration: 1 mg/mL

Reinigung: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

KCNQ4 (S43-6), Human hippocampus

KCNQ4 (S43-6), rat tissue lysate

Publikationen

Publikationen: Tatulian, Delmas, Abogadie et al.: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).

Kharkovets, Dedek, Maier et al.: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed).

Hernandez, Zaika, Tolstykh et al.: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed).