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FKBP4 Antikörper

FKBP4 Reaktivität: Human WB, IHC, IP, IF, ICC Wirt: Maus Monoclonal Hi52C unconjugated
Produktnummer ABIN361686
  • Target Alle FKBP4 Antikörper anzeigen
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    Reaktivität
    • 100
    • 31
    • 16
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 62
    • 36
    • 2
    Maus
    Klonalität
    • 57
    • 43
    Monoklonal
    Konjugat
    • 46
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FKBP4 Antikörper ist unkonjugiert
    Applikation
    • 82
    • 48
    • 38
    • 28
    • 19
    • 16
    • 15
    • 15
    • 14
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~52 kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
    Kreuzreaktivität
    Hund, Hamster, Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Synthetic peptide corresponding to the residues of human FKBP52
    Klon
    Hi52C
    Isotyp
    IgG2a
    Top Product
    Discover our top product FKBP4 Primärantikörper
  • Applikationshinweise
    • WB (1:2000)
    • IHC (1:250)
    • ICC/IF (1:1000)
    • IP (5 μg)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml was sufficient for detection of FKBP52 in 20 μg total protein using WB by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    Andere Bezeichnung
    FKBP52 (FKBP4 Produkte)
    Synonyme
    HBI antikoerper, p52 antikoerper, hsp56 antikoerper, PPIase antikoerper, fkbp52 antikoerper, fkbp59 antikoerper, MGC81078 antikoerper, wu:fb34f09 antikoerper, 59kDa antikoerper, AL022792 antikoerper, AW208983 antikoerper, FKBP-4 antikoerper, FKBP-52 antikoerper, FKBP52 antikoerper, FKPB52 antikoerper, p59 antikoerper, FKBP51 antikoerper, FKBP59 antikoerper, Hsp56 antikoerper, P59 antikoerper, FK506 binding protein 4 antikoerper, FK506 binding protein 4 S homeolog antikoerper, FKBP4 antikoerper, fkbp4.S antikoerper, fkbp4 antikoerper, Fkbp4 antikoerper
    Hintergrund
    HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
    Gen-ID
    2288
    NCBI Accession
    NP_002005
    UniProt
    Q02790
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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