UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) Antikörper

Antigen: UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A)

Synonyme: UPF3, HUPF3A, RENT3A, MGC151365, 2600001C03Rik, 4930546M19Rik, UPF3A, si:dkey-21o13.6

Klonalität: Polyklonal

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB), Immunfluoreszenz (IF)

Produktnummer: ABIN361622

Produktbeschreibung

Weitere Bezeichnung: UPF3A

Gen-ID: 65110

Immunogen: Recombinant protein of full length Human UPF3A

Format: Affinity-purified

Beschreibung: Function: Part of a multiprotein post-splicing mRNP complex involved in both mRNA nuclear export and mRNA surveillance. Involved innonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA upstream of exon-exon junctions Subcellular location: Nucleus. Cytoplasm. Note: Shuttling between the nucleus and the cytoplasm Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed infetal brain and spinal cord Sequence similarities: Belongs to the RENT3 family.

Anwendungen

Applikationshinweise: WB: 1ug/ml. IF: 10ug/ml

Konzentration: 0.5 mg/ml

Reinigung: Protein A purified

Buffer: PBS, pH 7.2

Lagerung: Store below -20 degrees Celsius

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

UPF3A transfected 293T cell lysate

HeLa cell 0 0

Publikationen

Publikationen: Serin, Gersappe, Black et al.: "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." in: Molecular and cellular biology, Vol. 21, Issue 1, pp. 209-23, 2001 (PubMed).

Lykke-Andersen, Shu, Steitz: "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon." in: Cell, Vol. 103, Issue 7, pp. 1121-31, 2001 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).