Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) Antikörper

Antigen: Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1)

Synonyme: AIF, PDCD8, MGC111425, aif, pdcd8, AIFM1, PCD8, DmelCG7263, GB16024

Klonalität: Polyklonal

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB), Immunfluoreszenz (IF)

Produktnummer: ABIN361613

Produktbeschreibung

Weitere Bezeichnung: PDCD8

Gen-ID: 9131

Immunogen: Recombinant protein of full length Human PDCD8

Format: Affinity-purified

Beschreibung: Function: Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. ExtramitochondrialAIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independentmanner Subcellular location: Mitochondrion intermembrane space. Nucleus. Note: Translocated to the nucleus upon induction of apoptosis Sequence similarities: Belongs to the FAD-dependent oxidoreductase family.

Anwendungen

Applikationshinweise: WB: 1ug/ml. IF: 10ug/ml

Konzentration: 1 mg/ml

Reinigung: Protein A purified

Buffer: PBS, pH 7.2

Lagerung: Store below -20 degrees Celsius

Forschungsgebiet: Enzyme

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

PDCD8 transfected 293T cell lysate

PDCD8 transfected 293T cell lysate

HeLa cell 0

Publikationen

Publikationen: Susin, Lorenzo, Zamzami et al.: "Molecular characterization of mitochondrial apoptosis-inducing factor." in: Nature, Vol. 397, Issue 6718, pp. 441-6, 1999 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).