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SMAD, Mothers Against DPP Homolog 6 (SMAD6) Antikörper
| Antigen | SMAD, Mothers Against DPP Homolog 6 (SMAD6) |
| Synonyme | MADH6, MADH7, HsT17432, madh6, madh7, Xsmad6, hst17432 |
| Klonalität | Polyklonal |
| Wirt |
Alternativen Maus |
| Reaktivität |
Alternativen Human |
| Applikation |
Alternativen Western Blot (WB), Durchflusszytometrie (FACS)
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3 Publikationen vorhanden |
| Produktnummer | ABIN361570 |
| Menge | 50 ug (0.46 mg/ml) |
| Preis | 521,45 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
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| Verfügbarkeit | Lieferung in 7 bis 10 Werktagen |
Produktbeschreibung
| Weitere Bezeichnung | SMAD6 |
| Gen-ID | 4091 |
| Immunogen | Recombinant protein of full length Human SMAD6 |
| Format | Affinity-purified |
| Beschreibung | Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain. |
Anwendungen
| Applikationshinweise | WB: 1ug/ml. FACS: 1ug/ml |
| Konzentration | 0.46 mg/ml |
| Reinigung | Protein A purified |
| Buffer | PBS, pH 7.2 |
| Lagerung | Store below -20 degrees Celsius |
| Forschungsgebiet | Signaltransduktion |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Bilder
| SMAD6 transfected 293T cell lysate. Negative control Transfectant SMAD6 expressing 293 cells 0 0 |
Publikationen
| Publikationen |
Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).
Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed). Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed). |
Alternativen
Alternativen zu Antigen "SMAD, Mothers Against DPP Homolog 6 (SMAD6)", Typ "Antikörper" finden
| Wirte | Maus (22), Kaninchen (15) |
| Reaktivitäten | Human (38), Maus (6), Ratte (Rattus) (5), Affe (2), Huhn (1), Rind (Kuh) (1), Hund (1) |
| Applikationen | Western Blot (WB) (36), Immunhistochemie (Paraffinschnitte) (IHC (p)) (15), Enzyme Immunoassay (EIA) (12), ELISA (9), ELISA (Detektionsantikörper) (3), Durchflusszytometrie (FACS) (2), Immunhistochemie (IHC) (2), Dot Blot (Dot) (1), Immunfluoreszenz (IF) (1), Immunpräzipitation (IP) (1) |




Alternativen