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SMAD, Mothers Against DPP Homolog 6 (SMAD6) Antikörper

Antigen

SMAD, Mothers Against DPP Homolog 6 (SMAD6)

Synonyme MADH6, MADH7, HsT17432, madh6, madh7, Xsmad6, hst17432
Klonalität Polyklonal
Wirt
Reaktivität
Alternativen

Human

Applikation
Alternativen Western Blot (WB), Durchflusszytometrie (FACS)
3 Publikationen vorhanden
Produktnummer ABIN361570
Menge 50 ug  (0.46 mg/ml)
Preis 521,45 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung

Weitere Bezeichnung SMAD6
Gen-ID 4091
Immunogen Recombinant protein of full length Human SMAD6
Format Affinity-purified
Beschreibung Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.

Anwendungen

Applikationshinweise WB: 1ug/ml. FACS: 1ug/ml
Konzentration 0.46 mg/ml
Reinigung Protein A purified
Buffer PBS, pH 7.2
Lagerung Store below -20 degrees Celsius
Forschungsgebiet Signaltransduktion
Beschränkungen Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Alternativen

Alternativen zu Antigen "SMAD, Mothers Against DPP Homolog 6 (SMAD6)", Typ "Antikörper" finden
Wirte Maus (22), Kaninchen (15)
Reaktivitäten Human (38), Maus (6), Ratte (Rattus) (5), Affe (2), Huhn (1), Rind (Kuh) (1), Hund (1)
Applikationen Western Blot (WB) (36), Immunhistochemie (Paraffinschnitte) (IHC (p)) (15), Enzyme Immunoassay (EIA) (12), ELISA (9), ELISA (Detektionsantikörper) (3), Durchflusszytometrie (FACS) (2), Immunhistochemie (IHC) (2), Dot Blot (Dot) (1), Immunfluoreszenz (IF) (1), Immunpräzipitation (IP) (1)