Regulator of G-Protein Signalling 6 (RGS6) Antikörper

Antigen: Regulator of G-Protein Signalling 6 (RGS6)

Synonyme: GAP, FLJ43552, MGC142132, DKFZp313G1241, RGS6, hm:zeh0300, si:ch211-268e23.2

Klonalität: Polyklonal

Wirt: Maus

Reaktivität: Human, Ratte (Rattus)

Applikation: Western Blot (WB), Durchflusszytometrie (FACS)

Produktnummer: ABIN361567

Produktbeschreibung

Weitere Bezeichnung: RGS6

Gen-ID: 9628

Immunogen: Recombinant protein of full length Human RGS6

Format: Affinity-purified

Beschreibung: Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactiveGDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer Subcellular location: Cytoplasm. Membrane, Peripheral membrane protein Sequence similarities: Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Anwendungen

Applikationshinweise: WB: 1ug/ml. FACS: 1ug/ml

Konzentration: 0.5 mg/ml

Reinigung: Protein A purified

Buffer: PBS, pH 7.2

Lagerung: Store below -20 degrees Celsius

Forschungsgebiet: Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

rat brain tissue lysate RGS6 transfected 293T cell lysate

rat brain tissue lysate RGS6 transfected 293T cell lysate

RGS6 expressing 293 cells. Negative control Transfectant

Publikationen

Publikationen: Snow, Betts, Mangion et al.: "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6489-94, 1999 (PubMed).

Posner, Gilman, Harris: "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 31087-93, 1999 (PubMed).

Chatterjee, Liu, Fisher: "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30261-71, 2003 (PubMed).