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Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antikörper

Antigen

Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)

Synonyme KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1, MGC133383, Trpm2-predicted, TRPM2, Trp7, Trrp7, C79133, 9830168K16Rik
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen

Reaktivität
Alternativen

Maus, Human, Ratte (Rattus)

Applikation
Alternativen ELISA, Western Blot (WB), Immunhistochemie (IHC), Immunzytochemie (ICC)
2 Publikationen vorhanden
Produktnummer ABIN361540
Menge 25 ug  (0.25 mg/ml)  (Varianten)
Preis 728,99 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung

Weitere Bezeichnung Trpm2
Gen-ID 28240
Immunogen Partial peptide of Mouse Trpm2 (C-terminal region)
Format Affinity-purified
Beschreibung Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress.Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activatedby ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellularATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.

Anwendungen

Applikationshinweise ELISA: 1ug/ml. WB: 1-5ug/ml. IHC: 5-10ug/ml. ICC: 1-5ug/ml.
Konzentration 0.25 mg/ml
Reinigung Antigen Affinity
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Lagerung Store below -20 degrees Celsius
Forschungsgebiet Kanäle
Beschränkungen Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen Hara, Wakamori, Ishii et al.: "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death." in: Molecular cell, Vol. 9, Issue 1, pp. 163-73, 2002 (PubMed).

Togashi, Hara, Tominaga et al.: "TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion." in: The EMBO journal, Vol. 25, Issue 9, pp. 1804-15, 2006 (PubMed).

Alternativen

Alternativen zu Antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)", Typ "Antikörper" finden
Wirte Kaninchen (28), Schaf (2)
Reaktivitäten Ratte (Rattus) (24), Human (23), Maus (23), Pferd (16), Hund (2), Schwein (2), Huhn (1), Rind (Kuh) (1), Kaninchen (1)
Applikationen Immunfluoreszenz (IF) (19), Western Blot (WB) (12), Immunhistochemie (IHC) (6), Immunpräzipitation (IP) (2), ELISA (1), Immunzytochemie (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Konjugate Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope C-Term (2), 3d extracellular loop (1), 4th cytoplasmic domain (1)