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Antikörper
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anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) An...
Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antikörper
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| Synonyme |
KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1, MGC133383, Trpm2-predicted, TRPM2, Trp7, Trrp7, C79133, 9830168K16Rik |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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Alternativen ELISA, Western Blot (WB), Immunhistochemie (IHC), Immunzytochemie (ICC)
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| Produktnummer |
ABIN361540 |
| Menge |
25 ug (0.25 mg/ml) (Varianten) |
| Preis |
728,99 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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Trpm2
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Gen-ID
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28240
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Immunogen
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Partial peptide of Mouse Trpm2 (C-terminal region)
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Format
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Affinity-purified
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Beschreibung
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Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress.Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activatedby ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellularATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.
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Applikationshinweise
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ELISA: 1ug/ml. WB: 1-5ug/ml. IHC: 5-10ug/ml. ICC: 1-5ug/ml.
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Konzentration
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0.25 mg/ml
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Reinigung
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Antigen Affinity
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Buffer
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PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
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Lagerung
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Store below -20 degrees Celsius
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Forschungsgebiet
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Kanäle
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Publikationen
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Hara, Wakamori, Ishii et al.: "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death." in: Molecular cell, Vol. 9, Issue 1, pp. 163-73, 2002 (PubMed).
Togashi, Hara, Tominaga et al.: "TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion." in: The EMBO journal, Vol. 25, Issue 9, pp. 1804-15, 2006 (PubMed).
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Alternativen zu Antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)", Typ "Antikörper" finden
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Wirte
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Kaninchen (28), Schaf (2)
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Reaktivitäten
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Ratte (Rattus) (24), Human (23), Maus (23), Pferd (16), Hund (2), Schwein (2), Huhn (1), Rind (Kuh) (1), Kaninchen (1)
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Applikationen
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Immunfluoreszenz (IF) (19), Western Blot (WB) (12), Immunhistochemie (IHC) (6), Immunpräzipitation (IP) (2), ELISA (1), Immunzytochemie (ICC) (1), Immunoelectron Microscopy (IEM) (1)
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Konjugate
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitope
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C-Term (2), 3d extracellular loop (1), 4th cytoplasmic domain (1)
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