GABA Transporter 3 (GAT3) Antikörper

Antigen: GABA Transporter 3 (GAT3)

Synonyme: SLC6A11, GAT3

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361452

Produktbeschreibung

Weitere Bezeichnung: GABA Transporter (GAT) 3

Format: Affinity-purified

Beschreibung: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996). Anti-GAT-3 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-3 protein.

Spezifität: Specific for the ~67k GAT-3 protein. Immunolabeling is blocked by the peptide used as antigen.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC: 1:100-1:200 Quality Control: Western blots performed on each lot.

Reinigung: Prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-3 protein.