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Produktdetails

anti-GABAA Receptor, d-Subunit, N-Terminus Antikörper

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Bild für anti-GABAA Receptor, d-Subunit, N-Terminus Antikörper
Antigen: GABAA Receptor, d-Subunit, N-Terminus
Klonalität: Polyklonal
Applikation: Western Blot (WB), Immunhistochemie (Gefrierschnitte) (IHC (fro))
Reaktivität: Ratte (Rattus), Maus
Wirt: Kaninchen
1 Publikation vorhanden 1 Publikation vorhanden
Menge: 100 µl
Preis: 298,51 €   (Zzgl. Versandkosten und MWSt)
Bestellnummer: ABIN361449
Verfügbarkeit: Lieferbar innerhalb von 5 bis 7 Werktagen
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Produktbeschreibung  » anti-GABAA Receptor, d-Subunit, N-Terminus Antikörper

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Antigen GABAA Receptor, d-Subunit, N-Terminus
Reaktivität Ratte (Rattus), Maus
Wirt Kaninchen
Klonalität Polyklonal
Format Affinitiy-purified
Beschreibung Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). More recently there have been a number of studies demonstrating that the d-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003, Wohlfarth et al., 2002). Anti-GABAA Receptor, d-Subunit  Western blot of mouse cerebellar lysates from wild type (Control) and d-knockout (d-K/O) animals showing specific immunolabeling of the ~52k d-subunit of the GABAA-R. The labeling was absent from a lysate prepared from d-knockout animals.
Spezifität Specific for the ~52k d-subunit of the GABAA receptor.

Anwendungen  » anti-GABAA Receptor, d-Subunit, N-Terminus Antikörper

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Applikation Western Blot (WB), Immunhistochemie (Gefrierschnitte) (IHC (fro))
» Hier finden Sie 3 Protokolle zu den gelisteten Anwendungen
Applikationshinweise Recommended Dilution: WB: 1:1000 IHC (frozen sections, Korpi et al. 2002): 1:250 IP: 10 µl per 50 µg lysate Quality Control: Western blots performed on each lot.
Reinigung Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
Lagerung Store at -20 °C, stable for 1 year
Beschränkungen Nur für Forschungszwecke einsetzbar

Publikationen  » anti-GABAA Receptor, d-Subunit, N-Terminus Antikörper

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Publikationen Uusi-Oukari, Kontturi, Coffey et al.: "AMPAR signaling mediating GABA(A)R delta subunit up-regulation in cultured mouse cerebellar granule cells." In: Neurochemistry international, 2010 (PubMed)