Fractin A Marker of Apoptosis Antikörper

Antigen: Fractin A Marker of Apoptosis

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361376

Produktbeschreibung

Beschreibung: Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer?s disease (Yang et al., 1998). It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press). Anti-Fractin Western blot of colchicine treated Sy5y cell lysate showing specific immunolabeling of the ~ 32k cleaved actin fragment (fractin).

Spezifität: Specific for the ~ 32 kDa fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1,000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Reinigung: neat serum.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of colchicine treated Sy5y cell lysate showing specific immunolabeling of the ~ 32k cleaved actin fragment (fractin).