Amyloid Beta A4 Precursor (APP) Antikörper

Antigen: Amyloid Beta A4 Precursor (APP)

Klonalität: Monoklonal (78-8)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN361267

Produktbeschreibung

Produktmerkmale: Positive control: Hela.
Cellular Localization: Cell Membrane

Swiss-Prot: P05067/P12023

Immunogen: This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of APP.

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Format: Liquid

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 78-8

Beschreibung: Amyloid beta precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein existing as several isoforms. The amino acid sequence of APP contains the amyloid domain (A-beta), which can be released by a two-step proteolytic cleavage. It is expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. APP acts as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It is also involved in cell mobility and transcription regulation through protein-protein interactions.

Spezifität: Cellular Localization: Cell Membrane. Molecular Weight: ~110kDa

Molekulargewicht: ~110kDa

Anwendungen

Applikationshinweise: WB: 1:500-1:1,000

Konzentration: 0.5mg/ml

Buffer: 1xTBS (pH7.4), 0.5%BSA, 25%Glycerol.

Konservierungsmittel: 0.05% Sodium Azide.

Lagerung: Store at +4° C after thawing. Aliquot store at -20° C or -80° C. Avoid repeated freeze / thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blot analysis on hela cell lysates using anti-APP monoclonal antibody