Phospholamban (PLN) Antikörper

Antigen: Phospholamban (PLN)

Synonyme: PLB, CMD1P, Plb, Plm, PLN, LOC100009299, MGC152249, LOC100226261, plb, cmd1p

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus), Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN361208

Produktbeschreibung

Weitere Bezeichnung: Phospholamban

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human Phospholamban, identical to the related rat and mouse sequence

Format: Affinity-purified

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca 2+ pump in cardiac muscle and skeletal muscle cells. 1 The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site. 2

Anwendungen

Applikationshinweise: Recommended Dilutions: WB 1ug/ml

Reinigung: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Lagerung: Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time.

Forschungsgebiet: Kardiovaskuläres System, Kontraktilität, Metabolismus, Aminosäuren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Phospholamban (PLN) antibody