Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (N-Term) Antikörper

Details zu Produkt Nr. ABIN360429, Anbieter: Anmelden zum Anzeigen
Antigen
  • MLK4
  • RP5-862P8.2
  • dJ862P8.3
  • Mlk4
  • mKIAA1804
  • mixed lineage kinase 4
  • cDNA sequence BC021891
  • KIAA1804
  • BC021891
  • LOC616014
  • LOC100345607
Epitop
N-Term
18
17
16
14
4
4
2
2
1
1
Reaktivität
Human
49
19
Wirt
Kaninchen
67
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
6
6
6
6
6
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
49
46
46
8
4
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLK4.
Isotyp Ig
Spezifität This antibody recognizes MLK4 (N-term). Other species not tested.
Reinigung Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Andere Bezeichnung MLK4 (KIAA1804 Antibody Abstract)
Hintergrund Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30 % of colorectal cancer contain at least one mutation in the tyrosine kinases, sampling of colorect cancer cells suggest an important role of MLK4 in this process. Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.Synonyms: KIAA1804, MLK4, Mitogen-activated protein kinase kinase kinase
Molekulargewicht 113957 Da
Gen-ID 84451, 9606
UniProt Q5TCX8
Forschungsgebiet Signaling
Applikationshinweise ELISA: 1/1,000 . Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Bilder des Herstellers
 image for anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (N-Term) antibody (ABIN360429) anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (N-Term) antibody
 image for anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (N-Term) antibody (ABIN360429) anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (N-Term) antibody (Image 2)
Allgemeine Veröffentlichungen Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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